Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 2/20 | 0.46 |
| ▸ | CTSK | P43235 | 2/20 | 0.46 |
| ▸ | CTSL | P07711 | 1/20 | 0.43 |
| ▸ | CTSB | P07858 | 1/20 | 0.43 |
| ▸ | REN | P00797 | 3/20 | 0.43 |
| ▸ | BACE1 | P56817 | 10/20 | 0.42 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.41 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7324479 | 0.89 | CTSS (0.47) | CTSSCTSKCTSLCTSBREN | |
| SCHEMBL7315478 | 0.86 | CTSS (0.59) | CTSSCTSKCTSLCTSBREN | |
| SCHEMBL7320746 | 0.82 | CTSS (0.53) | CTSSCTSKCTSLCTSBREN | |
| SCHEMBL7316868 | 0.82 | CTSS (0.53) | CTSSCTSKCTSLCTSBREN | |
| SCHEMBL7316871 | 0.82 | CTSS (0.55) | CTSSCTSKCTSLCTSBREN | |
| SCHEMBL10727619 | 0.82 | CTSS (0.62) | CTSSCTSKCTSLCTSBREN | |
| SCHEMBL7321496 | 0.78 | CTSS (0.43) | CTSSCTSKCTSLCTSBREN | |
| SCHEMBL17326876 | 0.78 | CTSS (0.56) | CTSSCTSKCTSLCTSBREN | |
| SCHEMBL7342116 | 0.77 | BACE1 (0.44) | CTSSCTSKCTSLCTSBREN | |
| SCHEMBL11020537 | 0.77 | CTSS (0.55) | CTSSCTSKCTSLCTSBREN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0272671-B1 | Aryloxy and arylacyloxy methyl ketones as thiol protease inhibitors | SANDOZ LTD (CH) | 1994-03-16 | — | — | EP | disclosed |
| US-5158936-A | Treating or prevention of tissue damage, inflammation, bone resporpption and muscular dystrophy | SYNTEX (U.S.A.) INC. (US) | 1992-10-27 | — | — | US | disclosed |
| US-5055451-A | Prevent tissue damage | SYNTEX INC. (US) | 1991-10-08 | — | — | US | disclosed |