Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 19/20 | 0.58 |
| ▸ | CTSL | P07711 | 8/20 | 0.50 |
| ▸ | CTSS | P25774 | 6/20 | 0.50 |
| ▸ | CTSB | P07858 | 5/20 | 0.50 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | CASP7 | P55210 | 1/20 | 0.44 |
| ▸ | CASP6 | P55212 | 1/20 | 0.44 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7450915 | 0.86 | CTSK (0.60) | CTSKCTSLCTSSCTSBCASP1 | |
| SCHEMBL7372135 | 0.86 | CTSK (0.67) | CTSKCTSLCTSSCTSBCASP1 | |
| SCHEMBL7346145 | 0.85 | CTSK (0.73) | CTSKCTSLCTSSCTSB | |
| SCHEMBL27492433 | 0.80 | CTSK (0.66) | CTSKCTSLCTSSCTSB | |
| SCHEMBL7341638 | 0.80 | CTSK (0.66) | CTSKCTSLCTSSCTSB | |
| SCHEMBL7379770 | 0.79 | CTSK (0.54) | CTSKCTSLCTSSCTSB | |
| SCHEMBL7448242 | 0.78 | CTSK (0.49) | CTSKCTSLCTSSCTSBCASP1 | |
| SCHEMBL27472820 | 0.78 | CTSK (0.49) | CTSKCTSLCTSSCTSBCASP1 | |
| SCHEMBL6581041 | 0.75 | CTSK (0.88) | CTSKCTSLCTSSCTSB | |
| SCHEMBL7664379 | 0.75 | CTSK (0.63) | CTSKCTSLCTSSCTSBCASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0804180-A4 | METHOD OF INHIBITING CATHEPSIN K | SMITHKLINE BEECHAM CORP (US) | 2001-09-05 | — | — | EP | disclosed |
| EP-0804180-A1 | METHOD OF INHIBITING CATHEPSIN K | SMITHKLINE BEECHAM CORPORATION (US) | 1997-11-05 | — | — | EP | disclosed |
| WO-1997016177-A9 | METHOD OF INHIBITING CATHEPSIN K | — | 1997-07-24 | — | — | WO | disclosed |
| WO-1997016177-A1 | METHOD OF INHIBITING CATHEPSIN K | SMITHKLINE BEECHAM CORPORATION (US) | 1997-05-09 | — | — | WO | disclosed |