Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3340978 | 0.86 | KDM4E (0.46) | ALDH1A1TDP1MAPTPOLBMAPK1 | |
| SCHEMBL6968035 | 0.85 | SMN1; SMN2 (0.48) | TP53HTTALDH1A1TDP1CYP3A4 | |
| SCHEMBL4482061 | 0.83 | ALDH1A1 (0.46) | HTTALDH1A1CYP3A4MAPTSMN1; SMN2 | |
| SCHEMBL4095909 | 0.81 | ALDH1A1 (0.58) | TP53HTTALDH1A1TDP1CYP3A4 | |
| SCHEMBL4095907 | 0.81 | ALDH1A1 (0.58) | TP53HTTALDH1A1TDP1CYP3A4 | |
| SCHEMBL7342175 | 0.80 | SMN1; SMN2 (0.50) | TP53HTTALDH1A1TDP1CYP3A4 | |
| SCHEMBL4279302 | 0.80 | MAPT (0.43) | ALDH1A1MAPTKDM4EKMT2A | |
| SCHEMBL11669455 | 0.79 | TP53 (0.51) | TP53HTTALDH1A1TDP1CYP3A4 | |
| SCHEMBL14915380 | 0.79 | HTT (0.43) | HTTALDH1A1TDP1CYP3A4POLB | |
| SCHEMBL2616867 | 0.77 | ALDH1A1 (0.51) | TP53HTTALDH1A1TDP1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6284796-B1 | NAPHTHAMIDINE COMPOUNDS | ABBOTT LABORATORIES | 2001-09-04 | — | — | US | disclosed |