Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 15/20 | 0.63 |
| ▸ | MMP2 | P08253 | 4/20 | 0.63 |
| ▸ | MMP13 | P45452 | 12/20 | 0.49 |
| ▸ | MMP1 | P03956 | 9/20 | 0.49 |
| ▸ | ADAM17 | P78536 | 5/20 | 0.49 |
| ▸ | MMP8 | P22894 | 2/20 | 0.49 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7342628 | 1.00 | MMP9 (0.63) | MMP9MMP2MMP13MMP1ADAM17 | |
| SCHEMBL13639252 | 0.91 | MMP9 (0.65) | MMP9MMP2MMP13MMP1ADAM17 | |
| SCHEMBL13639217 | 0.91 | MMP9 (0.65) | MMP9MMP2MMP13MMP1ADAM17 | |
| SCHEMBL25301517 | 0.91 | MMP9 (0.67) | MMP9MMP2MMP13MMP1ADAM17 | |
| SCHEMBL29521301 | 0.91 | MMP9 (0.67) | MMP9MMP2MMP13MMP1ADAM17 | |
| SCHEMBL25301518 | 0.91 | MMP9 (0.67) | MMP9MMP2MMP13MMP1ADAM17 | |
| SCHEMBL13639205 | 0.89 | MMP9 (0.66) | MMP9MMP2MMP13MMP1ADAM17 | |
| SCHEMBL13639187 | 0.89 | MMP9 (0.66) | MMP9MMP2MMP13MMP1ADAM17 | |
| SCHEMBL7345045 | 0.89 | TAS2R14 (0.54) | MMP9MMP2MMP13MMP8ALDH1A1 | |
| SCHEMBL7345042 | 0.89 | TAS2R14 (0.54) | MMP9MMP2MMP13MMP8ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0606046-B1 | Arylsulfonamido-substituted hydroxamic acids | CIBA GEIGY AG (CH) | 1997-10-08 | — | — | EP | disclosed |
| US-5646167-A | ADMINISTERED AS METALLOPROTEINASE INHIBITOR, ANTITUMOR OR ANTICARCINOGENIC AGENT | CIBA-GEIGY CORPORATION (US) | 1997-07-08 | — | — | US | disclosed |
| US-5506242-A | METALLOELASTASE INHIBITOR; TREATS EMPHYSEMA | CIBA-GEIGY CORPORATION (US) | 1996-04-09 | — | — | US | disclosed |
| US-5455258-A | Useful as inhibitors of matrix-degrading metalloproteinase enzymes such as stromelysin and/or collegenase | CIBA-GEIGY CORPORATION (US) | 1995-10-03 | — | — | US | disclosed |
| EP-0606046-A1 | Arylsulfonamido-substituted hydroxamic acids | CIBA-GEIGY AG (CH) | 1994-07-13 | — | — | EP | disclosed |