Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 11/20 | 0.48 |
| ▸ | F2 | P00734 | 9/20 | 0.45 |
| ▸ | F10 | P00742 | 5/20 | 0.45 |
| ▸ | F7 | P08709 | 3/20 | 0.45 |
| ▸ | PRSS1 | P07477 | 6/20 | 0.41 |
| ▸ | PLG | P00747 | 5/20 | 0.41 |
| ▸ | KLKB1 | P03952 | 5/20 | 0.41 |
| ▸ | PLAT | P00750 | 4/20 | 0.41 |
| ▸ | KLK1 | P06870 | 2/20 | 0.41 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.40 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10922460 | 0.82 | PLAU (0.54) | PLAUF2F10F7PRSS1 | |
| SCHEMBL10938176 | 0.81 | PLAU (0.48) | PLAUF2F10F7PRSS1 | |
| SCHEMBL7339710 | 0.80 | PLAU (0.60) | PLAUF2F10F7PRSS1 | |
| SCHEMBL10935567 | 0.80 | F2 (0.45) | PLAUF2F10F7PRSS1 | |
| SCHEMBL7338914 | 0.78 | PLAU (0.50) | PLAUF2F10PRSS1PLG | |
| SCHEMBL7341606 | 0.78 | PLAU (0.60) | PLAUF2F10F7PRSS1 | |
| SCHEMBL10917873 | 0.77 | PLAU (0.46) | PLAUF2F10F7PRSS1 | |
| SCHEMBL7350078 | 0.77 | PLAU (0.49) | PLAUF2F10PRSS1PLG | |
| SCHEMBL7342679 | 0.77 | FTO (0.55) | PLAUF2F10PRSS1PLG | |
| SCHEMBL7341764 | 0.77 | PLAU (0.51) | PLAUF2F10PRSS1PLG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0048433-B1 | NOVEL AMIDINE COMPOUNDS, PROCESS FOR PRODUCING SAME AND ANTI-COMPLEMENT AGENT COMPRISING THEM | TORII & CO., LTD. (JP) | 1986-05-28 | — | — | EP | disclosed |
| US-4532255-A | Amidine compounds and anticomplement agent comprising same | TORII & CO., LTD. (JP) | 1985-07-30 | — | — | US | disclosed |
| US-4454338-A | 6-AMIDINO-2-NATHTHYL-4-GUANIDINOBENZOATE | TORII & CO., LTD. (JP) | 1984-06-12 | — | — | US | disclosed |
| EP-0048433-A2 | Novel amidine compounds, process for producing same and anti-complement agent comprising them | TORII & CO., LTD. (JP) | 1982-03-31 | — | — | EP | disclosed |