SCHEMBL7342889

SCHEMBL7342889

CCOC(=O)C1=C(CCN2C(=O)c3ccccc3C2=O)NC(C)=C(C(=O)OC)C1c1cccc([N+](=O)[O-])c1

nearest known ligand 0.70

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HIF1A Q16665 3/20 0.70
CYP1A2 P05177 3/20 0.70
CYP3A4 P08684 3/20 0.70
CYP2C9 P11712 3/20 0.70
CYP2C19 P33261 3/20 0.70
MAPT P10636 3/20 0.70
MEN1 O00255 2/20 0.70
KMT2A Q03164 2/20 0.70
LMNA P02545 2/20 0.70
CYP2D6 P10635 2/20 0.70
TSHR P16473 2/20 0.70
NFKB1 P19838 2/20 0.70
POLB P06746 1/20 0.70
MAPK1 P28482 1/20 0.70
GPR55 Q9Y2T6 1/20 0.70
THPO P40225 1/20 0.70
CACNA1F O60840 9/20 0.64
CACNA1D Q01668 9/20 0.64
CACNA1S Q13698 9/20 0.64
CACNA1C Q13936 9/20 0.64

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7474114 0.88 HIF1A (0.62) HIF1ACYP1A2CYP3A4CYP2C9CYP2C19
SCHEMBL7350843 0.88 MAPT (0.70) HIF1ACYP1A2CYP3A4CYP2C9CYP2C19
SCHEMBL10918103 0.88 MAPT (0.70) HIF1ACYP1A2CYP3A4CYP2C9CYP2C19
SCHEMBL7343936 0.87 CACNA1C (0.63) HIF1ACYP1A2CYP3A4CYP2C9CYP2C19
SCHEMBL7274108 0.87 CACNA1F (0.75) HIF1ACYP1A2CYP3A4CYP2C9CYP2C19
SCHEMBL7279871 0.86 MAPT (0.66) HIF1ACYP1A2CYP3A4CYP2C9CYP2C19
SCHEMBL10742637 0.86 MAPT (0.69) HIF1ACYP1A2CYP3A4CYP2C9CYP2C19
SCHEMBL7342844 0.86 CACNA1F (0.62) HIF1ACYP1A2CYP3A4CYP2C9CYP2C19
SCHEMBL11451536 0.85 CACNA1F (0.52) HIF1ACYP1A2CYP3A4CYP2C9CYP2C19
SCHEMBL9672729 0.85 CACNA1F (0.68) HIF1ACYP1A2CYP3A4CYP2C9CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4849436-A TREATMENT OF CARDIOVASCULAR DISORDERS NELSON RESEARCH & DEVELOPMENT CO. (US) 1989-07-18 US disclosed
EP-0259462-A1 1,4-DIHYDROPYRIDINES Whitby Research Incorporated (US) 1988-03-16 EP disclosed
WO-1987005512-A1 1,4-DIHYDROPYRIDINES NELSON RESEARCH AND DEVELOPMENT COMPANY (US) 1987-09-24 WO disclosed