Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.56 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.45 |
| ▸ | MLYCD | O95822 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7141888 | 0.85 | SIGMAR1 (0.61) | SIGMAR1TAAR1KDM4EAOC3KMT2A | |
| SCHEMBL11179311 | 0.81 | NPC1 (0.53) | KDM4EAOC3KMT2AMEN1NPC1 | |
| SCHEMBL27817329 | 0.81 | SIGMAR1 (0.56) | SIGMAR1TAAR1KDM4EAOC3KMT2A | |
| SCHEMBL25439817 | 0.80 | SIGMAR1 (0.51) | SIGMAR1TAAR1KDM4EAOC3MLYCD | |
| SCHEMBL26327718 | 0.79 | SIGMAR1 (0.46) | SIGMAR1TAAR1KDM4ETDP1ALDH1A1 | |
| SCHEMBL1311254 | 0.79 | SIGMAR1 (0.57) | SIGMAR1TAAR1KDM4EAOC3KMT2A | |
| SCHEMBL11241047 | 0.77 | ALDH1A1 (0.46) | SIGMAR1TAAR1AOC3KMT2AMEN1 | |
| SCHEMBL27885210 | 0.77 | SIGMAR1 (0.65) | SIGMAR1TAAR1KDM4EAOC3 | |
| SCHEMBL8255372 | 0.76 | SIGMAR1 (0.69) | SIGMAR1TAAR1KDM4EAOC3 | |
| SCHEMBL8803464 | 0.76 | SIGMAR1 (0.50) | SIGMAR1TAAR1KDM4EAOC3KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5436240-A | Schizophrenia, Parkinson's disease, depression or hypotensive agents using tricyclic amines | THE UPJOHN COMPANY (US) | 1995-07-25 | — | — | US | disclosed |
| EP-0480939-B1 | HETEROCYCLIC AMINES HAVING CENTRAL NERVOUS SYSTEM ACTIVITY | UPJOHN CO (US) | 1995-01-25 | — | — | EP | disclosed |
| US-5273975-A | Heterocyclic amines having central nervous system activity | THE UPJOHN COMPANY (US) | 1993-12-28 | — | — | US | disclosed |
| EP-0480939-A1 | HETEROCYCLIC AMINES HAVING CENTRAL NERVOUS SYSTEM ACTIVITY. | UPJOHN CO (US) | 1992-04-22 | — | — | EP | disclosed |
| WO-1990015058-A1 | HETEROCYCLIC AMINES HAVING CENTRAL NERVOUS SYSTEM ACTIVITY | THE UPJOHN COMPANY (US) | 1990-12-13 | — | — | WO | disclosed |