Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 1/20 | 0.50 |
| ▸ | GDA | Q9Y2T3 | 1/20 | 0.50 |
| ▸ | POLA1 | P09884 | 2/20 | 0.47 |
| ▸ | CDK1 | P06493 | 4/20 | 0.46 |
| ▸ | CDK2 | P24941 | 3/20 | 0.46 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.46 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.46 |
| ▸ | MGMT | P16455 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PI4KA | P42356 | 2/20 | 0.40 |
| ▸ | PI4K2B | Q8TCG2 | 2/20 | 0.40 |
| ▸ | PI4K2A | Q9BTU6 | 2/20 | 0.40 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | XDH | P47989 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL669414 | 0.84 | PDPK1 (0.49) | PDPK1GDAPOLA1CDK1CDK2 | |
| SCHEMBL8588220 | 0.82 | DPP4 (0.47) | POLA1CDK1CDK2CCNB1CCNA2 | |
| SCHEMBL28274636 | 0.81 | PDPK1 (0.56) | PDPK1GDAPOLA1CDK1CDK2 | |
| SCHEMBL16145922 | 0.80 | POLA1 (0.55) | PDPK1GDAPOLA1CDK1CDK2 | |
| SCHEMBL8523000 | 0.78 | INSR (0.39) | CDK1CDK2CCNB1CCNA2CCNA1 | |
| SCHEMBL16146953 | 0.78 | POLA1 (0.56) | PDPK1GDAPOLA1CDK1CDK2 | |
| SCHEMBL8009122 | 0.78 | CDK1 (0.57) | PDPK1GDAPOLA1CDK1CDK2 | |
| SCHEMBL29138715 | 0.77 | PDPK1 (0.50) | PDPK1GDAPOLA1CDK1CDK2 | |
| SCHEMBL796828 | 0.77 | CDK1 (0.59) | PDPK1GDACDK1CDK2CCNB1 | |
| SCHEMBL16146295 | 0.77 | PDPK1 (0.50) | PDPK1GDAPOLA1CDK1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120156679-A1 | METHODS FOR MAKING TRANSCRIPTION PRODUCTS | EPICENTRE TECHNOLOGIES (US) | 2012-06-21 | — | — | US | disclosed |
| US-8137911-B2 | Using promoter sequences and RNA polymerase to generate nucleotide sequences corresponding to target gene sequences; gene expression inhibition and diagnostic probe generation | CELLSCRIPT, INC. (US) | 2012-03-20 | — | — | US | disclosed |
| US-7838270-B2 | Target-dependent transcription using deletion mutants of N4 RNA polymerase | THE UNIVERSITY OF CHICAGO (US) | 2010-11-23 | — | — | US | disclosed |
| US-7659072-B2 | Methods for using riboprimers for strand displacement replication of target sequences | EPICENTRE TECHNOLOGIES CORPORATION (US) | 2010-02-09 | — | — | US | disclosed |
| US-20080293107-A1 | METHODS FOR USING RIBOPRIMERS FOR STRAND DISPLACEMENT REPLICATION OF TARGET SEQUENCES | EPICENTRE TECHNOLOGIES CORPORATION (US) | 2008-11-27 | — | — | US | disclosed |
| EP-1576188-B1 | METHODS FOR USING RIBOPRIMERS FOR STRAND DISPLACEMENT REPLICATION OF TARGET SEQUENCES | EPICT TECHNOLOGIES (US) | 2008-10-15 | — | — | EP | disclosed |
| US-7413857-B2 | Methods for using riboprimers for strand displacement replication of target sequences | EPICENTRE TECHNOLOGIES (US) | 2008-08-19 | — | — | US | disclosed |
| EP-1585824-A4 | PREPARATION AND USE OF SINGLE-STRANDED TRANSCRIPTION SUBSTRATES FOR SYNTHESIS OF TRANSCRIPTION PRODUCTS CORRESPONDING TO TARGET SEQUENCES | EPICT TECHNOLOGIES (US) | 2008-01-02 | — | — | EP | disclosed |
| US-7101713-B1 | DNA transformation efficiency by inhibiting host cell restriction | EPICENTRE TECHNOLOGIES CORPORATION (US) | 2006-09-05 | — | — | US | disclosed |
| EP-1567675-A4 | METHODS FOR USING PRIMERS THAT ENCODE ONE STRAND OF A DOUBLE-STRANDED PROMOTER | EPICT TECHNOLOGIES (US) | 2006-05-10 | — | — | EP | disclosed |
| US-6277603-B1 | PEPTIDE NUCLEIC ACID (PNA); THE DNA PORTION IS COMPOSED OF SUBUNITS OF AT LEAST ONE 2'-DEOXYNUCLEOTIDES; INCREASED NUCLEASE RESISTANCE; ACTIVATE RNASE H ENZYME, USE FOR IN VITRO MODIFICATION OF RNA | ISIS PHARMACEUTICALS, INC. | 2001-08-21 | — | — | US | disclosed |
| EP-0590082-B1 | ANTISENSE OLIGONUCLEOTIDE INHIBITION OF THE RAS GENE | ISIS PHARMACEUTICALS INC (US) | 1999-10-27 | — | — | EP | disclosed |
| EP-0734391-A4 | PNA-DNA-PNA CHIMERIC MACROMOLECULES | ISIS PHARMACEUTICALS INC (US) | 1998-02-25 | — | — | EP | disclosed |
| US-5700922-A | INCREASED NUCLEASE RESISTANCE, INCREASED BINDING AFFINITY TO COMPLEMENTARY STRANDS; MEDICAL DIAGNOSIS, THERAPY | ISIS PHARMACEUTICALS, INC. (US) | 1997-12-23 | — | — | US | disclosed |
| US-5582986-A | OLIGONUCLEOTIDE TARGETED TO CODON 12 OF HUMAN H-RAS GENE, COMPLEMENTARY AND HYBRIDIZES TO MESSENGER RNA TO INTERFERE WITH NORMAL ROLE IN CELL, CAUSING LOSS OF FUNCTION | ISIS PHARMACEUTICALS, INC. (US) | 1996-12-10 | — | — | US | disclosed |
| EP-0734391-A1 | PNA-DNA-PNA CHIMERIC MACROMOLECULES | ISIS PHARMACEUTICALS, INC. (US) | 1996-10-02 | — | — | EP | disclosed |
| WO-1995014706-A1 | PNA-DNA-PNA CHIMERIC MACROMOLECULES | ISIS PHARMACEUTICALS, INC. (US) | 1995-06-01 | — | — | WO | disclosed |
| EP-0590082-A4 | ANTISENSE OLIGONUCLEOTIDE INHIBITION OF THE RAS GENE. | ISIS PHARMACEUTICALS INC (US) | 1995-04-12 | — | — | EP | disclosed |
| EP-0590082-A1 | ANTISENSE OLIGONUCLEOTIDE INHIBITION OF THE RAS GENE | ISIS PHARMACEUTICALS, INC. (US) | 1994-04-06 | — | — | EP | disclosed |
| WO-1992022651-A1 | ANTISENSE OLIGONUCLEOTIDE INHIBITION OF THE RAS GENE | ISIS PHARMACEUTICALS, INC. (US) | 1992-12-23 | — | — | WO | disclosed |