Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 3/20 | 0.59 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.56 |
| ▸ | CDK2 | P24941 | 3/20 | 0.56 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.56 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.56 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.56 |
| ▸ | MGMT | P16455 | 1/20 | 0.56 |
| ▸ | PRKACA | P17612 | 3/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.51 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.50 |
| ▸ | GDA | Q9Y2T3 | 1/20 | 0.50 |
| ▸ | BRAF | P15056 | 8/20 | 0.48 |
| ▸ | DPP4 | P27487 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16147021 | 0.80 | CDK1 (0.63) | CDK1NUDT1CDK2CCNB1CCNA2 | |
| SCHEMBL27820320 | 0.80 | PDPK1 (0.54) | CDK1NUDT1CDK2CCNB1CCNA2 | |
| SCHEMBL10838746 | 0.79 | NUDT1 (0.67) | CDK1NUDT1CDK2PRKACAHDAC1 | |
| SCHEMBL16146818 | 0.79 | TSHR (0.67) | CDK1NUDT1CDK2CCNB1CCNA2 | |
| SCHEMBL796827 | 0.78 | CDK1 (0.38) | CDK1NUDT1CDK2CCNB1CCNA2 | |
| SCHEMBL16146456 | 0.78 | NUDT1 (0.65) | CDK1NUDT1CDK2CCNB1CCNA2 | |
| SCHEMBL2052757 | 0.77 | CYP1A2 (0.67) | CDK2 | |
| SCHEMBL29542326 | 0.77 | CYP1A2 (0.67) | CDK2 | |
| SCHEMBL734360 | 0.77 | PDPK1 (0.50) | CDK1CDK2CCNB1CCNA2CCNA1 | |
| SCHEMBL16146485 | 0.77 | CDK1 (0.59) | CDK1NUDT1CDK2CCNB1CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490368-B1 | 2,2-BIS(HYDROXYMETHYL)CYCLOPROPYLIDENEMETHYL - PURINES AND -PYRIMIDINES AS ANTIVIRAL AGENTS | UNIV WAYNE STATE (US) | 2011-08-03 | — | — | EP | claimed |
| US-7393855-B2 | 2,2-bis-(hydroxymethyl)cyclopropylidenemethyl-purines and pyrimidines as antiviral agents | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2008-07-01 | — | — | US | claimed |
| EP-1490368-A4 | 2,2-BIS(HYDROXYMETHYL)CYCLOPROPYLIDENEMETHYL - PURINES AND -PYRIMIDINES AS ANTIVIRAL AGENTS | UNIV WAYNE STATE (US) | 2006-07-19 | — | — | EP | claimed |
| US-20050113393-A1 | 2,2-bis-(hydroxymethyl)cyclopropylidenemethyl-purines and pyrmindines as antiviral agents | WAYNE STATE UNIVERSITY (US) | 2005-05-26 | — | — | US | claimed |
| EP-1490368-A2 | 2,2-BIS(HYDROXYMETHYL)CYCLOPROPYLIDENEMETHYL - PURINES AND -PYRIMIDINES AS ANTIVIRAL AGENTS | Wayne State University (US) | 2004-12-29 | — | — | EP | claimed |
| WO-2003104440-A2 | 2,2-BIS(HYDROXYMETHYL)CYCLOPROPYLIDENEMETHYL - PURINES AND -PYRIMIDINES AS ANTIVIRAL AGENTS | WAYNE STATE UNIVERSITY (US) | 2003-12-18 | — | — | WO | claimed |
| US-20130231307-A1 | NOVEL ANTIVIRAL ACYCLIC NUCLEOSIDE PHOSPHONATES | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2013-09-05 | — | — | US | disclosed |
| EP-2616474-A1 | NOVEL ANTIVIRAL ACYCLIC NUCLEOSIDE PHOSPHONATES | Centre National De La Recherche Scientifique (FR) | 2013-07-24 | — | — | EP | disclosed |
| WO-2012034719-A1 | NOVEL ANTIVIRAL ACYCLIC NUCLEOSIDE PHOSPHONATES | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2012-03-22 | — | — | WO | disclosed |
| US-20060122203-A1 | 2-Hydroxymethylcyclopropylidenemethylpurines and - pyrimidines as antiviral agents | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2006-06-08 | — | — | US | disclosed |
| US-6958345-B2 | 2-hydroxymethylcyclopropylidene methylpurines and -pyrimidines as antiviral agents | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2005-10-25 | — | — | US | disclosed |
| US-20050009842-A1 | 2-hydroxymethylcyclopropylidene methylpurines and -pyrimidines as antiviral agents | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2005-01-13 | — | — | US | disclosed |
| US-6790841-B2 | FOR THERAPY OF MAMMAL INFECTED WITH VIRUS | WAYNE STATE UNIVERSITY | 2004-09-14 | — | — | US | disclosed |
| US-20020193353-A1 | 2-hydroxymethylcyclopropylidenemethylpurines and -pyrimidines as antiviral agents | WAYNE STATE UNIVERSITY | 2002-12-19 | — | — | US | disclosed |
| WO-2000053603-A9 | 2-HYDROXY METHYLCYCLOPRO PYLIDENEMETHYL PURINES AND -PYRIMIDINES AS ANTIVIRAL AGENTS | UNIV MICHIGAN (US) | 2002-05-10 | — | — | WO | disclosed |
| EP-1165560-A4 | 2-HYDROXY METHYLCYCLOPRO PYLIDENEMETHYL PURINES AND -PYRIMIDINES AS ANTIVIRAL AGENTS | UNIV MICHIGAN (US) | 2002-04-17 | — | — | EP | disclosed |
| US-6352991-B1 | VIRICIDES FOR TREATMENT OF AIDS | WAYNE STATE UNIVERSITY | 2002-03-05 | — | — | US | disclosed |
| EP-1165560-A1 | 2-HYDROXY METHYLCYCLOPRO PYLIDENEMETHYL PURINES AND -PYRIMIDINES AS ANTIVIRAL AGENTS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000053603-A1 | 2-HYDROXY METHYLCYCLOPRO PYLIDENEMETHYL PURINES AND -PYRIMIDINES AS ANTIVIRAL AGENTS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2000-09-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060122203-A1 | 2-Hydroxymethylcyclopropylidenemethylpurines and - pyrimidines as antiviral agents | HPRT1, TPMT, NUDT1 | CDK1 2402/4885NUDT1 3/4885CDK2 797/4885 |
| US-20050009842-A1 | 2-hydroxymethylcyclopropylidene methylpurines and -pyrimidines as antiviral agents | TPMT, HPRT1, MTAP | CDK1 2863/4885NUDT1 6/4885CDK2 824/4885 |
| US-20050113393-A1 | 2,2-bis-(hydroxymethyl)cyclopropylidenemethyl-purines and pyrmindines as antiviral agents | TPMT, HPRT1, MTAP | CDK1 3163/4885NUDT1 6/4885CDK2 566/4885 |
| US-20130231307-A1 | NOVEL ANTIVIRAL ACYCLIC NUCLEOSIDE PHOSPHONATES | PNP, TYMP, EIF2AK2 | CDK1 203/4885NUDT1 13/4885CDK2 370/4885 |
| US-20020193353-A1 | 2-hydroxymethylcyclopropylidenemethylpurines and -pyrimidines as antiviral agents | TPMT, HPRT1, MTAP | CDK1 2857/4885NUDT1 4/4885CDK2 1102/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.