Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9928632 | 1.00 | REN (0.47) | RENCYP3A4 | |
| SCHEMBL14788400 | 1.00 | REN (0.47) | RENCYP3A4 | |
| SCHEMBL14791593 | 0.90 | REN (0.48) | REN | |
| SCHEMBL16511409 | 0.90 | REN (0.48) | REN | |
| SCHEMBL14655570 | 0.90 | REN (0.48) | REN | |
| SCHEMBL4048454 | 0.90 | REN (0.48) | REN | |
| SCHEMBL12503115 | 0.90 | REN (0.48) | REN | |
| SCHEMBL16020531 | 0.89 | REN (0.49) | REN | |
| SCHEMBL9907059 | 0.88 | REN (0.46) | REN | |
| SCHEMBL1931894 | 0.88 | REN (0.46) | REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0678503-B1 | Delta-amino-gamma-hydroxy-omega-aryl alkanoic acid amides with enzyme especially renin inhibiting activities | NOVARTIS AG (CH) | 1999-09-01 | — | — | EP | claimed |
| US-5654445-A | INTERMEDIATES FOR RENIN INHIBITORS, HYPOTENSIVE AGENTS | CIBA-GEIGY CORPORATION (US) | 1997-08-05 | — | — | US | claimed |
| US-9346745-B2 | Process for producing Aliskiren | CHEMO IBERICA, S.A. (ES) | 2016-05-24 | — | — | US | disclosed |
| EP-2736875-B1 | CHEMICAL PROCESS FOR OPENING RING COMPOUNDS | CHEMO IBÉRICA S A (ES) | 2015-07-22 | — | — | EP | disclosed |
| US-9067868-B2 | Chemical process for opening ring compounds | CHEMO IBERICA, S.A. (ES) | 2015-06-30 | — | — | US | disclosed |
| US-9067868-B2 | Chemical process for opening ring compounds | CHEMO IBERICA, S.A. (ES) | 2015-06-30 | — | — | US | disclosed |
| EP-2546243-B1 | METHOD FOR PREPARING ALISKIREN | ZHEJIANG TIANYU PHARMACEUTICAL CO LTD (CN) | 2015-01-07 | — | — | EP | disclosed |
| US-20140213821-A1 | CHEMICAL PROCESS FOR OPENING RING COMPOUNDS | CHEMO IBERICA, S. A. (ES) | 2014-07-31 | — | — | US | disclosed |
| US-20140213821-A1 | CHEMICAL PROCESS FOR OPENING RING COMPOUNDS | CHEMO IBERICA, S. A. (ES) | 2014-07-31 | — | — | US | disclosed |
| US-8664440-B2 | Method for preparing aliskiren and its intermediates thereof | ZHEJIANG TIANYU PHARMACEUTICAL CO., LTD (CN) | 2014-03-04 | — | — | US | disclosed |
| US-20130225841-A1 | METHOD FOR PREPARING ALISKIREN AND ITS INTERMEDIATES THEREOF | ZHEJIANG TIANYU PHARMACEUTICAL CO., LTD. (CN) | 2013-08-29 | — | — | US | disclosed |
| WO-2013014191-A1 | CHEMICAL PROCESS FOR OPENING RING COMPOUNDS | CHEMO IBERICA, S. A. (ES) | 2013-01-31 | — | — | WO | disclosed |
| EP-2551260-A1 | Chemical process for opening ring compounds | Chemo Ibérica, S.A. (ES) | 2013-01-30 | — | — | EP | disclosed |
| EP-2546243-A1 | METHOD FOR PREPARING ALISKIREN AND INTERMEDIATE THEREOF | Zhejiang Tianyu Pharmaceutical Co., Ltd (CN) | 2013-01-16 | — | — | EP | disclosed |
| US-8203005-B2 | Manufacturing process for enantiomerically pure 8-aryloctanoic acids as Aliskiren | CARBO DESIGN LLC (US) | 2012-06-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130225841-A1 | METHOD FOR PREPARING ALISKIREN AND ITS INTERMEDIATES THEREOF | FLI1, MLX, LMTK2 | REN 166/4885CYP3A4 1335/4885 |
| US-20140213821-A1 | CHEMICAL PROCESS FOR OPENING RING COMPOUNDS | LSS, CILK1, DCXR | REN 2429/4885CYP3A4 231/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.