Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 7/20 | 0.48 |
| ▸ | POLB | P06746 | 5/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.48 |
| ▸ | CTSL | P07711 | 2/20 | 0.45 |
| ▸ | CTSB | P07858 | 1/20 | 0.45 |
| ▸ | CTSS | P25774 | 1/20 | 0.45 |
| ▸ | CTSK | P43235 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 9/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.45 |
| ▸ | MEN1 | O00255 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | RECQL | P46063 | 3/20 | 0.44 |
| ▸ | XBP1 | P17861 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | NPR3 | P17342 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6224857 | 0.85 | MAPT (0.48) | NPSR1POLBTDP1CTSLCTSB | |
| SCHEMBL7367580 | 0.85 | MAPT (0.48) | NPSR1POLBTDP1CTSLCTSB | |
| SCHEMBL10210577 | 0.83 | NPSR1 (0.50) | NPSR1POLBTDP1CTSLCTSB | |
| SCHEMBL22311674 | 0.83 | NPSR1 (0.47) | NPSR1POLBTDP1CTSLCTSB | |
| SCHEMBL12627973 | 0.83 | NPSR1 (0.50) | NPSR1POLBTDP1CTSLCTSB | |
| SCHEMBL28516209 | 0.83 | NPSR1 (0.47) | NPSR1POLBTDP1CTSLCTSB | |
| SCHEMBL27922423 | 0.81 | NPSR1 (0.46) | NPSR1POLBTDP1CTSLCTSB | |
| SCHEMBL21675512 | 0.81 | CTSK (0.61) | NPSR1POLBTDP1CTSLCTSB | |
| SCHEMBL27922427 | 0.81 | NPSR1 (0.46) | NPSR1POLBTDP1CTSLCTSB | |
| SCHEMBL13826663 | 0.81 | CTSL (0.43) | NPSR1POLBTDP1CTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6110896-A | TRIPEPTIDYL DERIVATIVES HAVING A MERCAPTO OR ACYLTHIO GROUP AND WHICH ARE AMIDES; UTILITY AS MATRIX METALLOPROTEASE OR TNF INHIBITORS | DARWIN DISCOVERY, LTD. (GB) | 2000-08-29 | — | — | US | disclosed |
| EP-0826000-A1 | PEPTIDE COMPOUNDS WHICH INHIBIT METALLOPROTEINASE AND TNF LIBERATION AND THEIR THERAPEUTIC USES | Chiroscience Limited (GB) | 1998-03-04 | — | — | EP | disclosed |
| WO-1996035714-A1 | PEPTIDE COMPOUNDS WHICH INHIBIT METALLOPROTEINASE AND TNF LIBERATION AND THEIR THERAPEUTIC USES | CHIROSCIENCE LIMITED (GB) | 1996-11-14 | — | — | WO | disclosed |