Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.67 |
| ▸ | HPGD | P15428 | 2/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.67 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.47 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | OGG1 | O15527 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13788236 | 0.87 | KCNA3 (0.55) | KDM4EALDH1A1HPGDTDP1KCNA3 | |
| SCHEMBL7870247 | 0.84 | KCNA3 (0.52) | KDM4EALDH1A1HPGDTDP1KCNA3 | |
| SCHEMBL3721611 | 0.83 | KCNA3 (0.54) | KDM4EALDH1A1HPGDTDP1KCNA3 | |
| SCHEMBL6999173 | 0.82 | PDE10A (0.50) | KDM4EALDH1A1KCNA3MAPK1GPBAR1 | |
| Naphthyloxyacetic Acid SCHEMBL29364154 | 0.80 | KDM4E (1.00) | KDM4EALDH1A1HPGDTDP1KCNA3 | |
| Naphthyloxyacetic Acid SCHEMBL120838 | 0.80 | KDM4E (1.00) | KDM4EALDH1A1HPGDTDP1KCNA3 | |
| SCHEMBL8546449 | 0.80 | CASP3 (0.54) | KDM4EALDH1A1HPGDTDP1KCNA3 | |
| SCHEMBL8546456 | 0.80 | CASP3 (0.54) | KDM4EALDH1A1HPGDTDP1KCNA3 | |
| Naphthyloxyacetic Acid SCHEMBL8441282 | 0.79 | KDM4E (0.96) | KDM4EALDH1A1HPGDTDP1KCNA3 | |
| Naphthyloxyacetic Acid SCHEMBL15201763 | 0.79 | KDM4E (0.96) | KDM4EALDH1A1HPGDTDP1KCNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1990005523-A2 | PHENANTHROLINEDICARBOXYLATE ESTERS, 4-AMINOQUINOLINE AND ISOQUINOLINE DERIVATIVES AS INHIBITORS OF HIV REVERSE TRANSCRIPTASE | THE UPJOHN COMPANY (US) | 1990-05-31 | — | — | WO | claimed |
| US-6329502-B1 | VIRICIDES AGAINST HUMAN IMMUNODEFICIENCY VIRUS; TREATMENT OF AIDS (ACQUIRED IMMUNE DEFICIENCY SYNDROME) | JAPAN ENERGY CORPORATION (JP) | 2001-12-11 | — | — | US | disclosed |
| US-6313094-B1 | COMPOSITION FOR INHIBITING HUMAN IMMUNODEFICIENCY VIRUS REPLICATION | JAPAN ENERGY CORPORATION (JP) | 2001-11-06 | — | — | US | disclosed |
| US-6291432-B1 | (R)-N-(2-METHYLBENZYL)-3-((2S, 3S)-3-(N-(2-CHROMONECARBONYL)-L-ASPARAGINYL)AMINO-2-HYDROXY-4-PHENYLBUTANO YL)-5,5-DIMETHYL-1,3-THIAZOLIDINE-4-CARBOXAMIDE CAN BE GIVEN AS A TYPICAL EXAMPLE OF THIS COMPOUND. | JAPAN ENERGY CORPORATION (JP) | 2001-09-18 | — | — | US | disclosed |
| EP-0490667-B1 | HIV protease inhibitors | JAPAN ENERGY CORP (JP) | 1999-06-09 | — | — | EP | disclosed |
| EP-0900566-A1 | NOVEL TRIPEPTIDE COMPOUNDS AND ANTI-AIDS DRUGS | JAPAN ENERGY CORPORATION (JP) | 1999-03-10 | — | — | EP | disclosed |
| EP-0574135-B1 | Process for producing peptide derivatives and salts thereof | JAPAN ENERGY CORP (JP) | 1998-11-18 | — | — | EP | disclosed |
| EP-0812839-A1 | Irreversible HIV protease inhibitors, compositions containing same and process for the preparation thereof | LG Chemical Limited (KR) | 1997-12-17 | — | — | EP | disclosed |
| EP-0812857-A1 | Irreversible HIV protease inhibitors, compositions containing same and process for the preparation thereof | LG Chemical Limited (KR) | 1997-12-17 | — | — | EP | disclosed |
| US-5679687-A | Irreversible HIV protease inhibitors, compositions containing same and process for the preparation thereof | LG CHEMICAL LIMITED (KR) | 1997-10-21 | — | — | US | disclosed |
| US-5670517-A | MULTISTAGE SYNTHESIS WITH EPOXIDATION, DECARBONYLATION, COUPLING BY AMIDATION THEN DECARBONYLATION | LG CHEMICAL LIMITED (KR) | 1997-09-23 | — | — | US | disclosed |
| US-5644028-A | Process for producing peptide derivatives and salts therefor | JAPAN ENERGY CORPORATION (JP) | 1997-07-01 | — | — | US | disclosed |
| EP-0574135-A1 | Process for producing peptide derivatives and salts thereof | JAPAN ENERGY CORPORATION (JP) | 1993-12-15 | — | — | EP | disclosed |
| EP-0490667-A2 | HIV protease inhibitors | JAPAN ENERGY CORPORATION (JP) | 1992-06-17 | — | — | EP | disclosed |
| WO-1990005523-A2 | PHENANTHROLINEDICARBOXYLATE ESTERS, 4-AMINOQUINOLINE AND ISOQUINOLINE DERIVATIVES AS INHIBITORS OF HIV REVERSE TRANSCRIPTASE | THE UPJOHN COMPANY (US) | 1990-05-31 | — | — | WO | disclosed |