Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TARS1 | P26639 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 5/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | CA9 | Q16790 | 2/20 | 0.41 |
| ▸ | LARS1 | Q9P2J5 | 5/20 | 0.40 |
| ▸ | CTSK | P43235 | 2/20 | 0.39 |
| ▸ | CTSS | P25774 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.39 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.39 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.39 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.39 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 6/20 | 0.38 |
| ▸ | MMP1 | P03956 | 4/20 | 0.36 |
| ▸ | ADAMTS4 | O75173 | 2/20 | 0.36 |
| ▸ | MMP14 | P50281 | 2/20 | 0.36 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.36 |
| ▸ | MMP9 | P14780 | 2/20 | 0.35 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7168553 | 0.95 | CTSK (0.42) | TARS1MMP2CA2CA9CTSK | |
| SCHEMBL7163920 | 0.85 | TARS1 (0.54) | TARS1MMP2CA2CA9LARS1 | |
| SCHEMBL7241035 | 0.83 | HSP90AA1 (0.43) | TARS1MMP2CA2CA9CTSK | |
| SCHEMBL7159422 | 0.83 | CTSK (0.56) | TARS1MMP2CA2CA9CTSK | |
| SCHEMBL7338790 | 0.83 | CTSK (0.47) | TARS1MMP2CA2CA9CTSK | |
| SCHEMBL7163244 | 0.75 | CTSK (0.46) | TARS1MMP2CA2CA9CTSK | |
| SCHEMBL19792904 | 0.70 | LARS1 (0.78) | TARS1MMP2LARS1CTSKCTSS | |
| SCHEMBL7244091 | 0.70 | CTSK (0.46) | TARS1MMP2CA2CA9CTSK | |
| SCHEMBL6622127 | 0.69 | CTSK (0.47) | LARS1CTSKCTSSAAK1 | |
| SCHEMBL7164038 | 0.69 | CTSK (0.62) | CTSKCTSSMMP13CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0804180-A4 | METHOD OF INHIBITING CATHEPSIN K | SMITHKLINE BEECHAM CORP (US) | 2001-09-05 | — | — | EP | disclosed |
| EP-0804180-A1 | METHOD OF INHIBITING CATHEPSIN K | SMITHKLINE BEECHAM CORPORATION (US) | 1997-11-05 | — | — | EP | disclosed |
| WO-1997016177-A1 | METHOD OF INHIBITING CATHEPSIN K | SMITHKLINE BEECHAM CORPORATION (US) | 1997-05-09 | — | — | WO | disclosed |