Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.43 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.43 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.43 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.43 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.43 |
| ▸ | CTSK | P43235 | 2/20 | 0.41 |
| ▸ | CTSS | P25774 | 1/20 | 0.41 |
| ▸ | TARS1 | P26639 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 7/20 | 0.40 |
| ▸ | CA2 | P00918 | 5/20 | 0.40 |
| ▸ | CA9 | Q16790 | 5/20 | 0.40 |
| ▸ | MMP13 | P45452 | 6/20 | 0.39 |
| ▸ | MMP1 | P03956 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ADAMTS4 | O75173 | 2/20 | 0.38 |
| ▸ | MMP14 | P50281 | 2/20 | 0.38 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.38 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7168553 | 0.88 | CTSK (0.42) | HSP90AA1HSP90AB1PDK1PDK2PDK3 | |
| SCHEMBL7344886 | 0.83 | TARS1 (0.42) | HSP90AA1HSP90AB1PDK1PDK2PDK3 | |
| SCHEMBL7244091 | 0.78 | CTSK (0.46) | HSP90AA1HSP90AB1PDK1PDK2PDK3 | |
| SCHEMBL7163920 | 0.78 | TARS1 (0.54) | HSP90AA1HSP90AB1PDK1PDK2PDK3 | |
| SCHEMBL7338790 | 0.76 | CTSK (0.47) | HSP90AA1HSP90AB1PDK1PDK2PDK3 | |
| SCHEMBL7159422 | 0.75 | CTSK (0.56) | CTSKCTSSTARS1MMP2CA2 | |
| SCHEMBL7163244 | 0.73 | CTSK (0.46) | HSP90AA1HSP90AB1PDK1PDK2PDK3 | |
| SCHEMBL7164038 | 0.71 | CTSK (0.62) | CTSKCTSSMMP13CA1 | |
| SCHEMBL7616420 | 0.70 | CTSK (0.44) | CTSKCTSSMMP2CA2CA9 | |
| SCHEMBL10407604 | 0.70 | ATM (0.39) | LMNAKDM4EALDH1A1HTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6586466-B2 | Enzyme inhibitor for use in the treatment of bone, oral, arthritic, paget's and hypercalcemic diseases | SMITHKLINE BEECHAM CORPORATION | 2003-07-01 | — | — | US | disclosed |
| US-20020077455-A1 | Protease inhibitors | SMITHKLINE BEECHAM CORPORATION | 2002-06-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020077455-A1 | Protease inhibitors | CTSK, CTSZ, CTSG | HSP90AA1 1382/4885HSP90AB1 1245/4885PDK1 1003/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.