Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 18/20 | 0.46 |
| ▸ | MMP9 | P14780 | 17/20 | 0.46 |
| ▸ | MMP3 | P08254 | 17/20 | 0.46 |
| ▸ | MMP7 | P09237 | 15/20 | 0.46 |
| ▸ | MMP13 | P45452 | 14/20 | 0.46 |
| ▸ | MMP2 | P08253 | 2/20 | 0.44 |
| ▸ | MMP8 | P22894 | 1/20 | 0.43 |
| ▸ | MMP12 | P39900 | 1/20 | 0.43 |
| ▸ | MMP14 | P50281 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6432038 | 0.89 | MMP1 (0.60) | MMP1MMP9MMP3MMP7MMP13 | |
| SCHEMBL7761459 | 0.84 | MMP9 (0.61) | MMP1MMP9MMP3MMP7MMP13 | |
| SCHEMBL7408927 | 0.84 | MMP9 (0.61) | MMP1MMP9MMP3MMP7MMP13 | |
| SCHEMBL6338966 | 0.84 | MMP9 (0.51) | MMP1MMP9MMP3MMP7MMP13 | |
| SCHEMBL6434571 | 0.83 | MMP1 (0.56) | MMP1MMP9MMP3MMP7MMP13 | |
| SCHEMBL6338089 | 0.76 | MMP1 (0.75) | MMP1MMP9MMP3MMP7MMP13 | |
| SCHEMBL6345919 | 0.75 | MMP1 (0.62) | MMP1MMP9MMP3MMP7MMP13 | |
| SCHEMBL7410369 | 0.75 | MMP1 (0.77) | MMP1MMP9MMP3MMP7MMP13 | |
| SCHEMBL6336332 | 0.75 | MMP1 (0.79) | MMP1MMP9MMP3MMP7MMP13 | |
| SCHEMBL7375954 | 0.75 | MMP1 (0.79) | MMP1MMP9MMP3MMP7MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0874830-A1 | METALLOPROTEINASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR PHARMACEUTICAL USES, AND METHODS AND INTERMEDIATES USEFUL FOR THEIR PREPARATION | AGOURON PHARMACEUTICALS, INC. (US) | 1998-11-04 | — | — | EP | disclosed |
| WO-1997020824-A1 | METALLOPROTEINASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR PHARMACEUTICAL USES, AND METHODS AND INTERMEDIATES USEFUL FOR THEIR PREPARATION | AGOURON PHARMACEUTICALS, INC. (US) | 1997-06-12 | — | — | WO | disclosed |