Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | EDNRB | P24530 | 5/20 | 0.38 |
| ▸ | EDNRA | P25101 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | FABP4 | P15090 | 2/20 | 0.36 |
| ▸ | FABP3 | P05413 | 1/20 | 0.36 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.36 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.36 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7339610 | 0.84 | HSP90AA1 (0.36) | HSP90AA1HSP90AB1EDNRBEDNRAALDH1A1 | |
| SCHEMBL7338558 | 0.76 | KDM4E (0.36) | PTGS2EDNRAALDH1A1KDM4EHPGD | |
| SCHEMBL7068384 | 0.68 | EDNRB (0.42) | EDNRBEDNRAALDH1A1HPGD | |
| SCHEMBL7065613 | 0.65 | MAPK1 (0.39) | PTGS2EDNRAALDH1A1KDM4EPKM | |
| SCHEMBL7831457 | 0.62 | CTNNB1 (0.55) | HSP90AA1HSP90AB1EDNRBEDNRAALDH1A1 | |
| SCHEMBL7065610 | 0.62 | EDNRB (0.47) | EDNRBEDNRAALDH1A1KDM4EPKM | |
| SCHEMBL7829178 | 0.61 | EDNRA (0.44) | PTGS2EDNRBEDNRAALDH1A1KDM4E | |
| SCHEMBL2945422 | 0.61 | ALDH1A1 (0.73) | ALDH1A1PKMMAPK1CTNNB1 | |
| SCHEMBL8085173 | 0.61 | ALDH1A1 (0.46) | EDNRBEDNRAALDH1A1KDM4EHPGD | |
| SCHEMBL1443004 | 0.60 | TP53 (0.61) | PTGS2EDNRBEDNRAALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0811001-B1 | BENZOTHIAZINE DIOXIDES AS ENDOTHELIN ANTAGONISTS | WARNER LAMBERT CO (US) | 2001-10-31 | — | — | EP | claimed |
| EP-0811001-A1 | BENZOTHIAZINE DIOXIDES AS ENDOTHELIN ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 1997-12-10 | — | — | EP | claimed |
| WO-1996026195-A1 | BENZOTHIAZINE DIOXIDES AS ENDOTHELIN ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 1996-08-29 | — | — | WO | claimed |