Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 5/20 | 0.78 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.78 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.78 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.78 |
| ▸ | HTR3E | A5X5Y0 | 4/20 | 0.56 |
| ▸ | HTR3B | O95264 | 4/20 | 0.56 |
| ▸ | HTR3D | Q70Z44 | 4/20 | 0.56 |
| ▸ | HTR3C | Q8WXA8 | 4/20 | 0.56 |
| ▸ | CNR2 | P34972 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9398052 | 1.00 | HTR3A (0.78) | HTR3AHTR4TMEM97SIGMAR1HTR3E | |
| SCHEMBL7343018 | 0.91 | HTR3A (0.85) | HTR3AHTR4TMEM97SIGMAR1HTR3E | |
| SCHEMBL9398539 | 0.91 | HTR3A (0.85) | HTR3AHTR4TMEM97SIGMAR1HTR3E | |
| SCHEMBL1041383 | 0.88 | HTR4 (1.00) | HTR3AHTR4TMEM97SIGMAR1HTR3E | |
| SCHEMBL6669870 | 0.88 | HTR4 (1.00) | HTR3AHTR4TMEM97SIGMAR1HTR3E | |
| Hydrochloric Acid SCHEMBL29386085 | 0.87 | HTR4 (0.98) | HTR3AHTR4TMEM97SIGMAR1HTR3E | |
| Hydrochloric Acid SCHEMBL8717464 | 0.87 | HTR4 (0.98) | HTR3AHTR4TMEM97SIGMAR1HTR3E | |
| Hydrochloric Acid SCHEMBL678218 | 0.86 | HTR4 (0.96) | HTR3AHTR4TMEM97SIGMAR1HTR3E | |
| Hydrochloric Acid SCHEMBL9572388 | 0.86 | HTR4 (0.96) | HTR3AHTR4TMEM97SIGMAR1HTR3E | |
| SCHEMBL4385500 | 0.85 | HTR4 (0.58) | HTR3AHTR4TMEM97SIGMAR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0523013-B1 | Use of benzimidazoline-2-oxo-1-carboxylic acid derivatives in the treatment of organic mental diseases | BOEHRINGER INGELHEIM ITALIA (IT) | 1994-12-21 | — | — | EP | disclosed |
| US-5358954-A | Antiserotonine agent, antiemetic, gastrointestinal disorders | BOEHRINGER INGELHEIM ITALIA (IT) | 1994-10-25 | — | — | US | disclosed |
| US-5223511-A | Benzimidazoline-2-oxo-1-carboxylic acid compounds useful as 5-HT receptor antagonists | BOEHRINGER INGELHEIM ITALIA S.P.A. (IT) | 1993-06-29 | — | — | US | disclosed |
| EP-0523013-A2 | Use of benzimidazoline-2-oxo-1-carboxylic acid derivatives in the treatment of organic mental diseases | BOEHRINGER INGELHEIM ITALIA S.p.A. (IT) | 1993-01-13 | — | — | EP | disclosed |