Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 3/20 | 0.70 |
| ▸ | ACKR3 | P25106 | 3/20 | 0.47 |
| ▸ | F2 | P00734 | 1/20 | 0.46 |
| ▸ | PLG | P00747 | 1/20 | 0.46 |
| ▸ | PLAT | P00750 | 1/20 | 0.46 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.46 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.46 |
| ▸ | PPM1D | O15297 | 7/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | PPARD | Q03181 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.40 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.40 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.40 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7336657 | 0.83 | NR1H4 (0.54) | PLAUF2PLGPLATKLKB1 | |
| SCHEMBL7345032 | 0.83 | PLAU (1.00) | PLAUF2PLGPLATKLKB1 | |
| SCHEMBL7340961 | 0.81 | PLAU (0.70) | PLAUF2PLGPLATKLKB1 | |
| SCHEMBL7344354 | 0.77 | NR1H4 (0.59) | PLAUNR1H4SIRT2SIRT1SIRT3 | |
| SCHEMBL7343081 | 0.77 | PLAU (0.67) | PLAUF2PLGPLATKLKB1 | |
| SCHEMBL7343089 | 0.77 | PLAU (0.67) | PLAUF2PLGPLATKLKB1 | |
| SCHEMBL7335937 | 0.76 | DEGS1 (0.57) | NR1H4MEN1NPC1RAB9AKMT2A | |
| SCHEMBL7344445 | 0.76 | PLAU (0.68) | PLAUF2PLGPLATKLKB1 | |
| SCHEMBL7341946 | 0.75 | PLAU (0.67) | PLAUF2PLGPLATKLKB1 | |
| SCHEMBL7337848 | 0.75 | PLAU (0.67) | PLAUF2PLGPLATKLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6284796-B1 | NAPHTHAMIDINE COMPOUNDS | ABBOTT LABORATORIES | 2001-09-04 | — | — | US | claimed |
| US-6284796-B1 | NAPHTHAMIDINE COMPOUNDS | ABBOTT LABORATORIES | 2001-09-04 | — | — | US | disclosed |