Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 19/20 | 1.00 |
| ▸ | PLG | P00747 | 11/20 | 0.66 |
| ▸ | KLKB1 | P03952 | 10/20 | 0.66 |
| ▸ | PRSS1 | P07477 | 10/20 | 0.66 |
| ▸ | PLAT | P00750 | 9/20 | 0.66 |
| ▸ | F2 | P00734 | 9/20 | 0.66 |
| ▸ | KLK1 | P06870 | 1/20 | 0.59 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.52 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7345040 | 0.83 | PLAU (0.70) | PLAUPLGKLKB1PRSS1PLAT | |
| SCHEMBL7336652 | 0.81 | PLAU (0.70) | PLAUPLGKLKB1PRSS1PLAT | |
| SCHEMBL7340950 | 0.79 | PLAU (1.00) | PLAUPLGKLKB1PRSS1PLAT | |
| SCHEMBL4324160 | 0.76 | PLAU (1.00) | PLAUPLGKLKB1PRSS1PLAT | |
| Trifluoroacetic Acid SCHEMBL7358911 | 0.76 | PLAU (0.62) | PLAUPLGKLKB1PRSS1PLAT | |
| SCHEMBL7344349 | 0.75 | PLAU (0.74) | PLAUPLGKLKB1PRSS1PLAT | |
| SCHEMBL9305779 | 0.74 | PLAU (0.71) | PLAUPLGKLKB1PRSS1PLAT | |
| SCHEMBL4330440 | 0.74 | PLAU (1.00) | PLAUPLGKLKB1PRSS1PLAT | |
| Trifluoroacetic Acid SCHEMBL7856136 | 0.74 | PLAU (0.86) | PLAUPLGKLKB1PRSS1PLAT | |
| SCHEMBL7335930 | 0.73 | PLAU (0.78) | PLAUPLGKLKB1PRSS1PLAT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6284796-B1 | NAPHTHAMIDINE COMPOUNDS | ABBOTT LABORATORIES | 2001-09-04 | — | — | US | claimed |
| US-6284796-B1 | NAPHTHAMIDINE COMPOUNDS | ABBOTT LABORATORIES | 2001-09-04 | — | — | US | disclosed |