Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.32 |
| ▸ | AKT1 | P31749 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7347509 | 0.71 | MAPKAPK2 (0.37) | KDM4EALDH1A1HPGDGLAMAPKAPK2 | |
| SCHEMBL5849169 | 0.71 | EPHX2 (0.50) | TSHRKMT2AKDM4EGAAMAPT | |
| SCHEMBL7117442 | 0.69 | ELANE (0.44) | KMT2AKDM4EMAPTALDH1A1RAB9A | |
| SCHEMBL6779226 | 0.68 | KMT2A (0.34) | KMT2AKDM4EMAPTALDH1A1MEN1 | |
| SCHEMBL7434663 | 0.67 | ALDH1A1 (0.42) | KMT2AKDM4EGAAMAPTALDH1A1 | |
| SCHEMBL6178813 | 0.66 | RAB9A (0.50) | TSHRKMT2AGAAMAPTMEN1 | |
| SCHEMBL6775183 | 0.66 | KMT2A (0.44) | KMT2AKDM4EALDH1A1GLAMEN1 | |
| SCHEMBL27561944 | 0.66 | EPHX2 (0.46) | KMT2AKDM4EGAAMAPTALDH1A1 | |
| SCHEMBL6437790 | 0.66 | MAPT (0.47) | KDM4EGAAMAPTALDH1A1HPGD | |
| SCHEMBL2001318 | 0.65 | GAA (0.59) | TSHRKMT2AKDM4EGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0850221-A1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1998-07-01 | — | — | EP | disclosed |
| WO-1997008145-A1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1997-03-06 | — | — | WO | disclosed |