Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.48 |
| ▸ | GLO1 | Q04760 | 3/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | SLC40A1 | Q9NP59 | 6/20 | 0.47 |
| ▸ | NFKBIA | P25963 | 2/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.47 |
| ▸ | RELA | Q04206 | 1/20 | 0.47 |
| ▸ | PLAU | P00749 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7348008 | 0.82 | TDP1 (0.52) | MEN1KMT2AL3MBTL1POLBNPC1 | |
| SCHEMBL7086950 | 0.78 | SMN1; SMN2 (0.42) | MEN1KMT2AL3MBTL1POLBNPC1 | |
| SCHEMBL379216 | 0.78 | GLO1 (0.59) | MEN1KMT2AL3MBTL1POLBNPC1 | |
| SCHEMBL7350772 | 0.76 | GAA (0.58) | MEN1KMT2AL3MBTL1POLBNPC1 | |
| SCHEMBL7670546 | 0.75 | BTK (0.40) | MEN1KMT2AL3MBTL1MAPTALDH1A1 | |
| SCHEMBL13337941 | 0.75 | MEN1 (0.56) | MEN1KMT2AL3MBTL1POLBNPC1 | |
| SCHEMBL2939028 | 0.74 | MEN1 (0.58) | MEN1KMT2AL3MBTL1POLBNPC1 | |
| SCHEMBL2283401 | 0.74 | KDR (0.56) | MEN1KMT2AL3MBTL1POLBNPC1 | |
| SCHEMBL7345496 | 0.74 | PLK1 (0.57) | MEN1KMT2AL3MBTL1POLBNPC1 | |
| SCHEMBL7352314 | 0.74 | LMNA (0.49) | MEN1KMT2ABLMHTTCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0729457-B1 | DIAMINOCYCLOBUTENE-3,4-DIONES AS SMOOTH MUSCLE RELAXANTS | AMERICAN HOME PROD (US) | 1998-12-23 | — | — | EP | claimed |
| EP-0729457-A1 | DIAMINOCYCLOBUTENE-3,4-DIONES AS SMOOTH MUSCLE RELAXANTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-09-04 | — | — | EP | claimed |
| WO-1995014005-A1 | DIAMINOCYCLOBUTENE-3,4-DIONES AS SMOOTH MUSCLE RELAXANTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-05-26 | — | — | WO | claimed |
| US-5401753-A | Smooth muscle relaxants for urogenital disorders | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-03-28 | — | — | US | claimed |
| EP-0729457-B1 | DIAMINOCYCLOBUTENE-3,4-DIONES AS SMOOTH MUSCLE RELAXANTS | AMERICAN HOME PROD (US) | 1998-12-23 | — | — | EP | disclosed |
| US-5506252-A | MUSCLE RELAXANTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-04-09 | — | — | US | disclosed |
| US-5403854-A | Smooth muscle relaxants | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-04-04 | — | — | US | disclosed |
| US-5401753-A | Smooth muscle relaxants for urogenital disorders | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-03-28 | — | — | US | disclosed |
| US-5397790-A | Smooth muscle relaxants | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-03-14 | — | — | US | disclosed |
| US-5354763-A | Smooth muscle relaxants | AMERICAN HOME PRODUCTS CORPORATION (US) | 1994-10-11 | — | — | US | disclosed |