Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKN1 | Q16512 | 1/20 | 0.41 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.41 |
| ▸ | BUB1 | O43683 | 2/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | CDC7 | O00311 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | NPY5R | Q15761 | 9/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | CDC25B | P30305 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7337834 | 0.89 | PKN2 (0.41) | PKN1PKN2BUB1SIGMAR1CDC7 | |
| SCHEMBL7345382 | 0.81 | KDM4E (0.55) | PKN1PKN2CDC7ALDH1A1HSD17B10 | |
| SCHEMBL7338904 | 0.80 | KDM4E (0.39) | PKN1PKN2SIGMAR1CDC7ALDH1A1 | |
| SCHEMBL7345043 | 0.76 | PKN1 (0.35) | PKN1PKN2BUB1SIGMAR1CDC7 | |
| SCHEMBL7340801 | 0.73 | AURKB (0.43) | PKN1PKN2BUB1SIGMAR1CDC7 | |
| SCHEMBL3599167 | 0.72 | MAOA (0.53) | PKN1PKN2SIGMAR1MAPK1CYP11B2 | |
| SCHEMBL29649256 | 0.72 | MAOA (0.53) | PKN1PKN2SIGMAR1MAPK1CYP11B2 | |
| SCHEMBL7338824 | 0.72 | KDM4E (0.48) | ALDH1A1HSD17B10KDM4EHPGDCYP11B2 | |
| Hydrochloric Acid SCHEMBL7258529 | 0.71 | MAOA (0.52) | PKN1PKN2SIGMAR1MAPK1CYP11B2 | |
| SCHEMBL7342347 | 0.71 | CES1 (0.44) | ALDH1A1HSD17B10POLBMAPTALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4511569-A | Tricyclic lactams and derivatives useful in increasing cardiac contractility | SCHERING CORPORATION (US) | 1985-04-16 | — | — | US | disclosed |
| EP-0102046-A1 | Tricyclic lactams, method for making them, pharmaceutical compositions containing them | SCHERING CORPORATION (US) | 1984-03-07 | — | — | EP | disclosed |