Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 3/20 | 0.43 |
| ▸ | INCENP | Q9NQS7 | 3/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.43 |
| ▸ | PKN2 | Q16513 | 3/20 | 0.41 |
| ▸ | PKN1 | Q16512 | 2/20 | 0.41 |
| ▸ | CDC7 | O00311 | 3/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | NPY5R | Q15761 | 6/20 | 0.33 |
| ▸ | BUB1 | O43683 | 2/20 | 0.33 |
| ▸ | AURKA | O14965 | 2/20 | 0.33 |
| ▸ | TTK | P33981 | 2/20 | 0.33 |
| ▸ | PDE4A | P27815 | 2/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7338490 | 0.92 | AURKB (0.44) | AURKBINCENPPDE3BPDE3APKN2 | |
| SCHEMBL7337644 | 0.85 | AURKB (0.46) | AURKBINCENPPDE3BPDE3ACDC7 | |
| SCHEMBL7337834 | 0.84 | PKN2 (0.41) | PKN2PKN1CDC7SIGMAR1KDM4E | |
| SCHEMBL7347683 | 0.83 | KDM4E (0.43) | PKN2PKN1CDC7SIGMAR1KDM4E | |
| SCHEMBL7346574 | 0.82 | KDM4E (0.39) | PKN2PKN1CDC7SIGMAR1KDM4E | |
| SCHEMBL7337464 | 0.81 | KDM4E (0.55) | PDE3BPDE3APKN2PKN1CDC7 | |
| SCHEMBL7345733 | 0.80 | CYP2A6 (0.46) | PDE3BPDE3AKDM4EALDH1A1HPGD | |
| SCHEMBL7338016 | 0.78 | KDM4E (0.58) | PDE3BPDE3APKN2PKN1CDC7 | |
| SCHEMBL11121162 | 0.75 | AURKB (0.42) | AURKBINCENPPDE3BPDE3AKDM4E | |
| SCHEMBL7338656 | 0.74 | CYP11B2 (0.36) | PKN2PKN1CDC7KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4511569-A | Tricyclic lactams and derivatives useful in increasing cardiac contractility | SCHERING CORPORATION (US) | 1985-04-16 | — | — | US | disclosed |
| EP-0102046-A1 | Tricyclic lactams, method for making them, pharmaceutical compositions containing them | SCHERING CORPORATION (US) | 1984-03-07 | — | — | EP | disclosed |