Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 8/20 | 0.44 |
| ▸ | DRD2 | P14416 | 6/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7352124 | 0.82 | KCNH2 (0.33) | HTR1A | |
| SCHEMBL7352464 | 0.82 | KCNH2 (0.33) | HTR1A | |
| SCHEMBL7345110 | 0.77 | — | — | |
| SCHEMBL7352535 | 0.77 | — | — | |
| SCHEMBL7346213 | 0.77 | KDM4E (0.46) | SIGMAR1DRD2KDM4EHTR1ADRD3 | |
| SCHEMBL7354193 | 0.74 | HTR1A (0.36) | SIGMAR1SLC6A4HTR1A | |
| SCHEMBL7357631 | 0.70 | HTR1A (0.62) | SIGMAR1DRD2SLC6A4SLC6A3KDM4E | |
| SCHEMBL14078779 | 0.68 | HTR1A (0.63) | SIGMAR1DRD2SLC6A4SLC6A3KDM4E | |
| SCHEMBL8179864 | 0.66 | SIGMAR1 (0.56) | SIGMAR1DRD2SLC6A4SLC6A3KDM4E | |
| SCHEMBL8708311 | 0.65 | EPHX2 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0972764-A1 | Aminoalcohols and aminoketones as CNS active agents | Universita Degli Studi di Firenze (IT) | 2000-01-19 | — | — | EP | claimed |
| EP-0972764-A1 | Aminoalcohols and aminoketones as CNS active agents | Universita Degli Studi di Firenze (IT) | 2000-01-19 | — | — | EP | disclosed |