Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 2/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.62 |
| ▸ | HTR2A | P28223 | 3/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.62 |
| ▸ | HTR2C | P28335 | 2/20 | 0.62 |
| ▸ | MPO | P05164 | 1/20 | 0.62 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.62 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.62 |
| ▸ | HTR1D | P28221 | 1/20 | 0.62 |
| ▸ | HTR1B | P28222 | 1/20 | 0.62 |
| ▸ | HTR7 | P34969 | 1/20 | 0.62 |
| ▸ | CTSK | P43235 | 1/20 | 0.62 |
| ▸ | HTR6 | P50406 | 1/20 | 0.62 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.62 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.62 |
| ▸ | HTR1A | P08908 | 3/20 | 0.61 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31366243 | 1.00 | SLC6A4 (0.63) | SLC6A4CYP3A4HTR2ACYP1A2CYP2D6 | |
| SCHEMBL29441817 | 0.95 | SLC6A4 (0.61) | SLC6A4CYP3A4HTR2ACYP1A2CYP2D6 | |
| SCHEMBL734204 | 0.95 | SLC6A4 (0.61) | SLC6A4CYP3A4HTR2ACYP1A2CYP2D6 | |
| SCHEMBL1518996 | 0.93 | SLC6A4 (0.59) | SLC6A4CYP3A4HTR2ACYP1A2CYP2D6 | |
| SCHEMBL1518978 | 0.93 | SLC6A4 (0.59) | SLC6A4CYP3A4HTR2ACYP1A2CYP2D6 | |
| SCHEMBL29391207 | 0.93 | SLC6A4 (0.59) | SLC6A4CYP3A4HTR2ACYP1A2CYP2D6 | |
| SCHEMBL1518985 | 0.93 | SLC6A4 (0.59) | SLC6A4CYP3A4HTR2ACYP1A2CYP2D6 | |
| SCHEMBL1519001 | 0.93 | SLC6A4 (0.59) | SLC6A4CYP3A4HTR2ACYP1A2CYP2D6 | |
| SCHEMBL1293186 | 0.93 | SLC6A4 (0.59) | SLC6A4CYP3A4HTR2ACYP1A2CYP2D6 | |
| SCHEMBL28649099 | 0.93 | SLC6A4 (0.59) | SLC6A4CYP3A4HTR2ACYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 264 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114276288-B | Synthesis method and application of chiral alpha-propargyl-3-indole compound and derivative thereof | 中山大学 | 2023-11-03 | — | — | CN | claimed |
| US-20120094977-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF DISEASE ASSOCIATED WITH TRP-P8 EXPRESSION | DENDREON CORPORATION (US) | 2012-04-19 | — | — | US | claimed |
| EP-1957488-B1 | 3-AMINO-2-ARYLPROPYL AZAINDOLES AND USES THEREOF | HOFFMANN LA ROCHE (CH) | 2009-09-09 | — | — | EP | claimed |
| EP-1957488-A1 | 3-AMINO-2-ARYLPROPYL AZAINDOLES AND USES THEREOF | F.HOFFMANN-LA ROCHE AG (CH) | 2008-08-20 | — | — | EP | claimed |
| EP-1663962-A4 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF DISEASE ASSOCIATED WITH TRP-P8 EXPRESSION | DENDREON CORP (US) | 2007-08-22 | — | — | EP | claimed |
| WO-2007062998-A1 | 3-AMINO-2-ARYLPROPYL AZAINDOLES AND USES THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2007-06-07 | — | — | WO | claimed |
| JP-2007503392-A | — | — | 2007-02-22 | — | — | JP | claimed |
| EP-1663962-A2 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF DISEASE ASSOCIATED WITH TRP-P8 EXPRESSION | DENDREON CORPORATION (US) | 2006-06-07 | — | — | EP | claimed |
| US-20050113357-A1 | Muscarinic agonists | ANDERSON CARL-MAGNUS A (DK) | 2005-05-26 | — | — | US | claimed |
| US-20050054651-A1 | Compositions and methods for the treatment of disease associated with Trp-p8 expression | DENDREON CORPORATION (US) | 2005-03-10 | — | — | US | claimed |
| WO-2005020897-A2 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF DISEASE ASSOCIATED WITH TRP-P8 EXPRESSION | DENDREON CORPORATION (US) | 2005-03-10 | — | — | WO | claimed |
| EP-1278741-A1 | MUSCARINIC AGONISTS | Acadia Pharmaceuticals Inc. (US) | 2003-01-29 | — | — | EP | claimed |
| US-20020037886-A1 | Muscarinic agonists | ACADIA PHARMACEUTICALS INC. | 2002-03-28 | — | — | US | claimed |
| WO-2001083472-A1 | MUSCARINIC AGONISTS | ACADIA PHARMACEUTICALS, INC. (US) | 2001-11-08 | — | — | WO | claimed |
| EP-0439796-B1 | Indolylpropanols, process for their preparation, and their use and preparations containing them | BEIERSDORF LILLY GMBH (DE) | 1996-01-24 | — | — | EP | claimed |
| EP-0297380-B1 | Indolyl propanols, process for their preparation, their uses and preparation containing them | BEIERSDORF LILLY GMBH (DE) | 1994-10-05 | — | — | EP | claimed |
| US-5145849-A | Inotropic and antiarrythmia agents; sodium channel inhibitors | BEIERSDORF AKTIENGESELLSCHAFT (DE) | 1992-09-08 | — | — | US | claimed |
| US-4935414-A | New indolylpropanols, processes for their preparation and their use, and preparations containing the compounds | BEIERSDORF AG (DE) | 1990-06-19 | — | — | US | claimed |
| JP-4210979-A | — | — | None | — | — | JP | disclosed |
| EP-0297380-A2 | Indolyl propanols, process for their preparation, their uses and preparation containing them | Beiersdorf-Lilly GmbH (DE) | 1989-01-04 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020037886-A1 | Muscarinic agonists | CHRM2, CHRM1, CHRM4 | SLC6A4 972/4885CYP3A4 695/4885HTR2A 235/4885 |
| US-20120094977-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF DISEASE ASSOCIATED WITH TRP-P8 EXPRESSION | TRPC4, TRPC3, TRPC1 | SLC6A4 130/4885CYP3A4 4129/4885HTR2A 168/4885 |
| US-20050054651-A1 | Compositions and methods for the treatment of disease associated with Trp-p8 expression | TRPC4, TRPC3, TRPC1 | SLC6A4 130/4885CYP3A4 4129/4885HTR2A 168/4885 |
| US-20050113357-A1 | Muscarinic agonists | CHRM2, CHRM1, CHRM4 | SLC6A4 972/4885CYP3A4 695/4885HTR2A 235/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.