Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 10/20 | 0.46 |
| ▸ | ITGAV | P06756 | 10/20 | 0.46 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.46 |
| ▸ | ITGB1 | P05556 | 3/20 | 0.44 |
| ▸ | ITGB5 | P18084 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | ITGB6 | P18564 | 6/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.36 |
| ▸ | ITGB8 | P26012 | 1/20 | 0.36 |
| ▸ | ITGA8 | P53708 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7345509 | 0.97 | MEN1 (0.46) | ITGB3ITGAVITGA2BITGB1ITGB5 | |
| SCHEMBL7368777 | 0.89 | MEN1 (0.42) | ITGB3ITGAVITGA2BITGB1ITGB5 | |
| SCHEMBL7349898 | 0.88 | ITGB3 (0.42) | ITGB3ITGAVITGA2BITGB1ITGB5 | |
| SCHEMBL7372242 | 0.84 | ITGB3 (0.56) | ITGB3ITGAVITGA2BITGB1ITGB5 | |
| SCHEMBL7337256 | 0.82 | L3MBTL1 (0.48) | RAB9ATDP1KMT2AMEN1L3MBTL1 | |
| SCHEMBL7339623 | 0.82 | L3MBTL1 (0.46) | ITGB3ITGAVITGA2BRAB9ATDP1 | |
| SCHEMBL7337272 | 0.80 | L3MBTL1 (0.45) | ITGB3ITGAVITGA2BRAB9ATDP1 | |
| SCHEMBL7341616 | 0.80 | L3MBTL1 (0.45) | ITGB3ITGAVITGA2BRAB9ATDP1 | |
| SCHEMBL7341988 | 0.80 | L3MBTL1 (0.45) | ITGB3ITGAVITGA2BRAB9ATDP1 | |
| SCHEMBL7349856 | 0.80 | ITGB3 (0.46) | ITGB3ITGAVITGA2BITGB1ITGB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0850221-A1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1998-07-01 | — | — | EP | disclosed |
| WO-1997008145-A1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1997-03-06 | — | — | WO | disclosed |