SCHEMBL7346113

SCHEMBL7346113

O=S1(=O)N=CCCc2ccccc21

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA12 O43570 3/20 0.40
CA1 P00915 3/20 0.40
CA2 P00918 3/20 0.40
CA9 Q16790 3/20 0.40
RAB9A P51151 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.35
GPR3 P46089 1/20 0.32
SIGMAR1 Q99720 1/20 0.32
ALDH1A1 P00352 1/20 0.31
TSHR P16473 1/20 0.31
NPC1 O15118 1/20 0.31
MAPK13 O15264 1/20 0.31
MAPK12 P53778 1/20 0.31
MAPK11 Q15759 1/20 0.31
MAPK14 Q16539 1/20 0.31
NOS3 P29474 1/20 0.31
NOS1 P29475 1/20 0.31
NOS2 P35228 1/20 0.31
CES1 P23141 1/20 0.30
CA4 P22748 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL349152 0.79 CA12 (0.42) CA12CA1CA2CA9RAB9A
SCHEMBL2763395 0.73 RAB9A (0.37) CA12CA1CA2CA9RAB9A
SCHEMBL2782984 0.72 CA12 (0.39) CA12CA1CA2CA9RAB9A
SCHEMBL1463955 0.71 GPR3 (0.34) CA12CA1CA2CA9RAB9A
SCHEMBL465345 0.69 CA12 (0.37) CA12CA1CA2CA9RAB9A
SCHEMBL19820978 0.69 GPR3 (0.52) CA12CA1CA2CA9RAB9A
SCHEMBL61667 0.66 CA1 (0.47) CA12CA1CA2CA9RAB9A
SCHEMBL11750709 0.66 CES1 (0.39) CA12CA1CA2CA9RAB9A
SCHEMBL30533792 0.66 CA1 (0.47) CA12CA1CA2CA9RAB9A
Hydrochloric Acid SCHEMBL11752423 0.64 CES1 (0.38) CA12CA1CA2CA9RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0938477-A4 BENZOTHIAZO AND RELATED HETEROCYCLIC GROUP-CONTAINING CYSTEINE AND SERINE PROTEASE INHIBITORS CEPHALON INC (US) 1999-12-29 EP disclosed
US-5952328-A MAY BE USED TO ALLEVIATE, MEDIATE, REDUCE AND/OR PREVENT DISORDERS WHICH ARE ASSOCIATED WITH ABNORMAL AND/OR ABERRANT ACTIVITY OF CYSTEINE PROTEASES AND/OR SERINE PROTEASES CEPHALON, INC. (US) 1999-09-14 US disclosed
EP-0938477-A1 BENZOTHIAZO AND RELATED HETEROCYCLIC GROUP-CONTAINING CYSTEINE AND SERINE PROTEASE INHIBITORS CEPHALON, INC. (US) 1999-09-01 EP disclosed
WO-1998021186-A1 BENZOTHIAZO AND RELATED HETEROCYCLIC GROUP-CONTAINING CYSTEINE AND SERINE PROTEASE INHIBITORS CEPHALON, INC. (US) 1998-05-22 WO disclosed