Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 10/20 | 0.56 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.55 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.55 |
| ▸ | PLG | P00747 | 5/20 | 0.52 |
| ▸ | KLK1 | P06870 | 4/20 | 0.52 |
| ▸ | PLAT | P00750 | 3/20 | 0.52 |
| ▸ | PRSS1 | P07477 | 5/20 | 0.51 |
| ▸ | F2 | P00734 | 4/20 | 0.51 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.51 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | F12 | P00748 | 1/20 | 0.46 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.46 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.46 |
| ▸ | F10 | P00742 | 1/20 | 0.43 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4687383 | 0.88 | TRIM24 (0.66) | PLAUTRIM24TRIM33PRSS1F2 | |
| SCHEMBL7342926 | 0.79 | PLAU (0.74) | PLAUPLGKLK1PLATPRSS1 | |
| SCHEMBL7433812 | 0.79 | UNG (0.60) | PLGPRSS1F2F12PRSS2 | |
| SCHEMBL10227496 | 0.77 | TRIM24 (0.54) | TRIM24TRIM33CA12CA1CA2 | |
| Hydrochloric Acid SCHEMBL6816751 | 0.77 | UNG (0.58) | PLGPRSS1F2PRSS2PRSS3 | |
| SCHEMBL12607522 | 0.76 | TRIM24 (0.73) | TRIM24TRIM33CA12CA1CA2 | |
| SCHEMBL11770226 | 0.73 | TRIM24 (0.71) | TRIM24TRIM33CA12CA1CA2 | |
| SCHEMBL346974 | 0.73 | TRIM24 (0.64) | TRIM24TRIM33CA12CA1CA2 | |
| SCHEMBL7333988 | 0.73 | PLAU (1.00) | PLAUPLGKLK1PLATPRSS1 | |
| Trifluoroacetic Acid SCHEMBL7345645 | 0.72 | PLAU (0.59) | PLAUPLGKLK1PLATPRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20010049374-A1 | Urokinase inhibitors | STEELE ANDREW W (US) | 2001-12-06 | — | — | US | disclosed |
| US-6284796-B1 | NAPHTHAMIDINE COMPOUNDS | ABBOTT LABORATORIES | 2001-09-04 | — | — | US | disclosed |
| US-6258822-B1 | ENZYME INHIBITORS OF NAPHTHALENE AMIDINE COMPOUNDS | ABBOTT LABORATORIES | 2001-07-10 | — | — | US | disclosed |
| EP-1000018-A2 | UROKINASE INHIBITORS | Abbott Laboratories (US) | 2000-05-17 | — | — | EP | disclosed |
| WO-1999005096-A2 | UROKINASE INHIBITORS | ABBOTT LABORATORIES (US) | 1999-02-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010049374-A1 | Urokinase inhibitors | SERPINE1, PLAU, SERPINB1 | PLAU 2/4885TRIM24 3680/4885TRIM33 4726/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.