Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 11/20 | 0.72 |
| ▸ | MMP2 | P08253 | 11/20 | 0.72 |
| ▸ | MMP8 | P22894 | 5/20 | 0.72 |
| ▸ | MMP13 | P45452 | 5/20 | 0.72 |
| ▸ | MMP1 | P03956 | 4/20 | 0.72 |
| ▸ | MMP3 | P08254 | 3/20 | 0.72 |
| ▸ | MMP7 | P09237 | 3/20 | 0.72 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.62 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.62 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.62 |
| ▸ | ADAMTS4 | O75173 | 3/20 | 0.59 |
| ▸ | CA12 | O43570 | 1/20 | 0.56 |
| ▸ | CA9 | Q16790 | 1/20 | 0.56 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.56 |
| ▸ | MMP14 | P50281 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | CA1 | P00915 | 1/20 | 0.54 |
| ▸ | CA2 | P00918 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6723663 | 1.00 | MMP9 (0.72) | MMP9MMP2MMP8MMP13MMP1 | |
| SCHEMBL6723666 | 1.00 | MMP9 (0.72) | MMP9MMP2MMP8MMP13MMP1 | |
| SCHEMBL5839717 | 0.88 | MMP9 (0.92) | MMP9MMP2MMP8MMP13MMP1 | |
| SCHEMBL2161452 | 0.88 | MMP9 (0.92) | MMP9MMP2MMP8MMP13MMP1 | |
| SCHEMBL2161549 | 0.88 | MMP9 (0.92) | MMP9MMP2MMP8MMP13MMP1 | |
| SCHEMBL6394008 | 0.88 | MMP9 (0.64) | MMP9MMP2MMP8MMP13MMP1 | |
| SCHEMBL7087648 | 0.88 | MMP9 (0.64) | MMP9MMP2MMP8MMP13MMP1 | |
| SCHEMBL5093836 | 0.88 | MMP9 (0.64) | MMP9MMP2MMP8MMP13MMP1 | |
| SCHEMBL7376000 | 0.85 | MMP9 (0.74) | MMP9MMP2MMP8MMP13MMP1 | |
| SCHEMBL6321142 | 0.85 | MMP2 (0.58) | MMP9MMP2MMP8MMP13MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0606046-B1 | Arylsulfonamido-substituted hydroxamic acids | CIBA GEIGY AG (CH) | 1997-10-08 | — | — | EP | disclosed |
| US-5672615-A | MATRIX-DEGRADING METALLOPROTEINASE INHIBITORS | NOVARTIS CORPORATION (US) | 1997-09-30 | — | — | US | disclosed |
| US-5646167-A | ADMINISTERED AS METALLOPROTEINASE INHIBITOR, ANTITUMOR OR ANTICARCINOGENIC AGENT | CIBA-GEIGY CORPORATION (US) | 1997-07-08 | — | — | US | disclosed |
| US-5552419-A | METALLOPROTEINASE INHIBITORS | CIBA-GEIGY CORPORATION (US) | 1996-09-03 | — | — | US | disclosed |
| US-5506242-A | METALLOELASTASE INHIBITOR; TREATS EMPHYSEMA | CIBA-GEIGY CORPORATION (US) | 1996-04-09 | — | — | US | disclosed |
| US-5455258-A | Useful as inhibitors of matrix-degrading metalloproteinase enzymes such as stromelysin and/or collegenase | CIBA-GEIGY CORPORATION (US) | 1995-10-03 | — | — | US | disclosed |
| EP-0606046-A1 | Arylsulfonamido-substituted hydroxamic acids | CIBA-GEIGY AG (CH) | 1994-07-13 | — | — | EP | disclosed |