SCHEMBL734717

SCHEMBL734717

Cc1ccccc1C([NH])=O

nearest known ligand 0.62

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
HPGD P15428 3/20 0.50
ERCC5 P28715 1/20 0.48
FEN1 P39748 1/20 0.48
HTT P42858 1/20 0.47
NPC1 O15118 1/20 0.46
RAB9A P51151 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.46
MYC P01106 1/20 0.45
KDM4E B2RXH2 1/20 0.45
ALDH1A1 P00352 1/20 0.45
HSD17B10 Q99714 1/20 0.45
KMT2A Q03164 2/20 0.44
POLB P06746 1/20 0.44
ELANE P08246 1/20 0.44
TYK2 P29597 1/20 0.44
MEN1 O00255 1/20 0.43
ESR1 P03372 1/20 0.43
ESR2 Q92731 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3652206 0.81 ESR1 (0.49) HPGDHTTNPC1RAB9AMYC
SCHEMBL9545865 0.81 ALDH1A1 (0.53) HPGDSMN1; SMN2KDM4EALDH1A1HSD17B10
SCHEMBL29387256 0.79 CYP3A4 (0.55) HPGDERCC5FEN1HTTSMN1; SMN2
SCHEMBL166603 0.79 HPGD (0.54) HPGDERCC5FEN1HTTSMN1; SMN2
SCHEMBL333141 0.79 CYP3A4 (0.55) HPGDERCC5FEN1HTTSMN1; SMN2
SCHEMBL29425530 0.79 HPGD (0.54) HPGDERCC5FEN1HTTSMN1; SMN2
SCHEMBL777261 0.78 NPC1 (0.53) HPGDERCC5FEN1HTTNPC1
SCHEMBL29436920 0.78 NPC1 (0.53) HPGDERCC5FEN1HTTNPC1
SCHEMBL127127 0.78 NPC1 (0.53) HPGDERCC5FEN1HTTNPC1
SCHEMBL11607257 0.78 CYP1A2 (0.54) HPGDMYCKDM4EALDH1A1HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 360 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110603250-A Herbicidal 4-difluoromethylbenzamides 拜耳作物科学股份公司 2019-12-20 CN claimed
EP-2182950-B1 USE OF 4-(PYRROLIDIN-1-YL)QUINOLINE COMPOUNDS TO KILL CLINICALLY LATENT MICROORGANISMS HELPERBY THERAPEUTICS LTD (GB) 2017-07-19 EP claimed
EP-3116871-A1 USE OF N-(1,3,4-OXADIAZOL-2-YL)ARYLCARBOXAMIDES OR THEIR SALTS FOR CONTROLLING UNWANTED PLANTS IN AREAS OF TRANSGENIC CROP PLANTS BEING TOLERANT TO HPPD INHIBITOR HERBICIDES Bayer CropScience Aktiengesellschaft (DE) 2017-01-18 EP claimed
WO-2015135946-A1 USE OF N-(1,3,4-OXADIAZOL-2-YL)ARYLCARBOXAMIDES OR THEIR SALTS FOR CONTROLLING UNWANTED PLANTS IN AREAS OF TRANSGENIC CROP PLANTS BEING TOLERANT TO HPPD INHIBITOR HERBICIDES BAYER CROPSCIENCE AG (DE) 2015-09-17 WO claimed
US-8765780-B2 Alicyclic carboxylic acid derivatives of benzomorphans and related scaffolds, medicaments containing such compounds and their use BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2014-07-01 US claimed
US-20060058553-A1 Novel bicyclic hydroxamates as inhibitors of histone deacetylase AXYS PHARMACEUTICALS, INC. (US) 2006-03-16 US claimed
EP-1472216-A2 NOVEL BICYCLIC HYDROXAMATES AS INHIBITORS OF HISTONE DEACETYLASE Axys Pharmaceuticals (US) 2004-11-03 EP claimed
WO-2003066579-A2 NOVEL BICYCLIC HYDROXAMATES AS INHIBITORS OF HISTONE DEACETYLASE AXYS PHARMACEUTICALS (US) 2003-08-14 WO claimed
WO-2001092420-A2 PERYLENE DYES WITH PERSISTENT FLUORESCENCE CAUSED BY STERIC INHIBITION OF AGGREGATION RADIANT COLOR N.V. (BE) 2001-12-06 WO claimed
US-6004536-A USED FOR STAINING MEMBRANES IN CELLS OR ISOLATED FROM CELLS, ARE WELL-RETAINED THEREIN MOLECULAR PROBES, INC. (US) 1999-12-21 US claimed
EP-0446748-A2 Use of perylenedyes for the preparation of write, print or copying materials RIEDEL-DE HAEN AKTIENGESELLSCHAFT (DE) 1991-09-18 EP claimed
WO-2024121779-A1 PAPAIN-LIKE PROTEASE (PLPRO) INHIBITORS PFIZER INC. (US) 2024-06-13 WO disclosed
CN-113677773-B Room temperature curable organopolysiloxane composition for oil seal and automobile part 信越化学工业株式会社 2024-03-01 CN disclosed
CN-117425733-A Substance detection method using acylated amino acid hydrolase 学校法人常翔学园 2024-01-19 CN disclosed
EP-3661901-B1 SYNTHESIS OF GLYCOLS VIA TRANSFER HYDROGENATION OF ALPHA-FUNCTIONAL ESTERS WITH ALCOHOLS EASTMAN CHEM CO (US) 2023-12-06 EP disclosed
EP-0094911-A2 Preparation of pyrrolo-(3,4-c) pyrroles CIBA-GEIGY AG (CH) 1983-11-23 EP disclosed
US-4415685-A POLYMERIC FLUORESCENT RED DYES; LACQUERS; TONERS; VARNISHES; FIBERS; PLASTICS; COLOR FASTNESS CIBA-GEIGY CORPORATION (US) 1983-11-15 US disclosed
EP-0061426-A1 Process for colouring highly molecular organic material and polycyclic pigments CIBA-GEIGY AG (CH) 1982-09-29 EP disclosed
EP-0011849-B1 2,4,6-TRIIODO-ISOPHTHALAMIC ACID DERIVATIVES, THEIR PREPARATION AND X-RAY CONTRAST AGENTS BASED ON THESE COMPOUNDS SCHERING AKTIENGESELLSCHAFT (DE) 1982-05-19 EP disclosed
EP-0001617-B1 DIAZOTYPE MATERIAL HOECHST AKTIENGESELLSCHAFT (DE) 1981-07-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060058553-A1 Novel bicyclic hydroxamates as inhibitors of histone deacetylase HDAC1, HDAC2, HDAC11 HPGD 188/4885ERCC5 2195/4885FEN1 2134/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.