Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | F7 | P08709 | 5/20 | 0.43 |
| ▸ | PELI1 | Q96FA3 | 3/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.39 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7347491 | 1.00 | PDE4A (0.43) | PDE4APDE4BF7PELI1PTPN1 | |
| SCHEMBL7359628 | 0.87 | PDE4A (0.47) | PDE4APDE4BF7PELI1PTPN1 | |
| SCHEMBL7349929 | 0.87 | PELI1 (0.43) | PDE4APDE4BF7PELI1PTPN1 | |
| SCHEMBL7352837 | 0.87 | PDE4A (0.42) | PDE4APDE4BF7PELI1PTPN1 | |
| SCHEMBL7349935 | 0.87 | PELI1 (0.43) | PDE4APDE4BF7PELI1PTPN1 | |
| SCHEMBL7352832 | 0.87 | PDE4A (0.42) | PDE4APDE4BF7PELI1PTPN1 | |
| SCHEMBL7349224 | 0.83 | F7 (0.46) | PDE4APDE4BF7PELI1PTPN1 | |
| SCHEMBL7349221 | 0.83 | F7 (0.46) | PDE4APDE4BF7PELI1PTPN1 | |
| SCHEMBL7357532 | 0.82 | ALDH1A1 (0.46) | PDE4APDE4BF7PELI1PTPN1 | |
| SCHEMBL7357536 | 0.82 | ALDH1A1 (0.46) | PDE4APDE4BF7PELI1PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0834508-B1 | Substituted biphenyl or phenylpyridine derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 2001-08-16 | — | — | EP | disclosed |
| US-5877190-A | PHOSPHODIESTERASE INHIBITOR | ADIR ET COMPAGNIE (FR) | 1999-03-02 | — | — | US | disclosed |
| EP-0834508-A1 | Substituted biphenyl or phenylpyridine derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1998-04-08 | — | — | EP | disclosed |