Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 2/20 | 0.48 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.48 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.48 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.48 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.48 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.48 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 2/20 | 0.40 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4413845 | 0.83 | CHRM1 (0.60) | CHRM1CHRNB2CHRNA4CHRM2CHRM4 | |
| SCHEMBL11039555 | 0.78 | CHRM1 (0.54) | CHRM1CHRNB2CHRNA4CHRM2CHRM4 | |
| SCHEMBL7346742 | 0.78 | CHRM2 (0.54) | CHRM1CHRNB2CHRNA4CHRM2CHRM4 | |
| SCHEMBL15438002 | 0.78 | MGAM (0.41) | CHRM1ALDH1A1GAALMNAMAPK1 | |
| SCHEMBL3901813 | 0.77 | CHRM1 (0.58) | CHRM1CHRNB2CHRNA4CHRM2CHRM4 | |
| SCHEMBL12535776 | 0.76 | TSHR (0.37) | SMN1; SMN2GAACA12CA1CA2 | |
| SCHEMBL27643498 | 0.76 | ALDH1A1 (0.36) | ALDH1A1CYP1A2GAATHRBMAPT | |
| SCHEMBL10081258 | 0.76 | CHRM1 (0.52) | CHRM1CHRNB2CHRNA4CHRM2CHRM4 | |
| SCHEMBL5382868 | 0.74 | DNM1 (0.62) | CHRM1CHRNB2CHRNA4CHRM2CHRM4 | |
| SCHEMBL3038090 | 0.74 | DNM1 (0.68) | CHRM1CHRNB2CHRNA4CHRM2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0891978-B1 | 5H-Thiazolo (3,2-a) pyrimidine derivatives | HOFFMANN LA ROCHE (CH) | 2002-03-20 | — | — | EP | disclosed |
| US-5958931-A | NERVOUS SYSTEM DISORDERS | HOFFMANN-LA ROCHE INC. (US) | 1999-09-28 | — | — | US | disclosed |
| EP-0891978-A2 | 5H-Thiazolo (3,2-a) pyrimidine derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1999-01-20 | — | — | EP | disclosed |