Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 18/20 | 1.00 |
| ▸ | DRD2 | P14416 | 6/20 | 0.71 |
| ▸ | DRD3 | P35462 | 6/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6507236 | 0.83 | HTR1A (1.00) | HTR1ADRD2DRD3 | |
| SCHEMBL30730650 | 0.83 | HTR1A (1.00) | HTR1ADRD2DRD3 | |
| SCHEMBL7342606 | 0.82 | HTR1A (1.00) | HTR1ADRD2DRD3 | |
| Sumanirole SCHEMBL154412 | 0.81 | HTR1A (1.00) | HTR1ADRD2DRD3 | |
| Sumanirole SCHEMBL6269816 | 0.81 | HTR1A (1.00) | HTR1ADRD2DRD3 | |
| Sumanirole SCHEMBL30503038 | 0.81 | HTR1A (1.00) | HTR1ADRD2DRD3 | |
| Sumanirole SCHEMBL29518262 | 0.81 | HTR1A (1.00) | HTR1ADRD2DRD3 | |
| Sumanirole SCHEMBL5906552 | 0.80 | HTR1A (0.97) | HTR1ADRD2DRD3 | |
| SCHEMBL5424144 | 0.78 | HTR1A (0.70) | HTR1ADRD2DRD3 | |
| SCHEMBL7343780 | 0.76 | HTR1A (1.00) | HTR1ADRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5436240-A | Schizophrenia, Parkinson's disease, depression or hypotensive agents using tricyclic amines | THE UPJOHN COMPANY (US) | 1995-07-25 | — | — | US | disclosed |
| EP-0480939-B1 | HETEROCYCLIC AMINES HAVING CENTRAL NERVOUS SYSTEM ACTIVITY | UPJOHN CO (US) | 1995-01-25 | — | — | EP | disclosed |
| US-5273975-A | Heterocyclic amines having central nervous system activity | THE UPJOHN COMPANY (US) | 1993-12-28 | — | — | US | disclosed |
| WO-1990015058-A1 | HETEROCYCLIC AMINES HAVING CENTRAL NERVOUS SYSTEM ACTIVITY | THE UPJOHN COMPANY (US) | 1990-12-13 | — | — | WO | disclosed |