Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 9/20 | 1.00 |
| ▸ | DRD3 | P35462 | 9/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | CASP1 | P29466 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7348015 | 1.00 | DRD2 (1.00) | DRD2DRD3CYP2D6TSHRNFKB1 | |
| SCHEMBL14869628 | 0.86 | DRD2 (0.76) | DRD2DRD3CYP2D6TSHRNFKB1 | |
| Hydrochloric Acid SCHEMBL26692355 | 0.85 | DRD2 (0.73) | DRD2DRD3CYP2D6TSHRNFKB1 | |
| Hydrochloric Acid SCHEMBL31210148 | 0.85 | DRD2 (0.73) | DRD2DRD3CYP2D6TSHRNFKB1 | |
| SCHEMBL31523251 | 0.84 | DRD2 (0.73) | DRD2DRD3CYP2D6TSHRNFKB1 | |
| SCHEMBL2227921 | 0.83 | DRD2 (0.71) | DRD2DRD3CYP2D6TSHRNFKB1 | |
| SCHEMBL377452 | 0.81 | DRD2 (0.69) | DRD2DRD3CYP2D6TSHRNFKB1 | |
| SCHEMBL30809964 | 0.81 | DRD2 (0.69) | DRD2DRD3CYP2D6TSHRNFKB1 | |
| SCHEMBL4875328 | 0.81 | DRD2 (0.67) | DRD2DRD3CYP2D6TSHRNFKB1 | |
| SCHEMBL25305365 | 0.77 | DRD2 (0.62) | DRD2DRD3CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0641320-B1 | SUBSTITUTED (S)-3-PHENYLPIPERIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS DOPAMINE AUTORECEPTOR ANTAGONISTS | UPJOHN CO (US) | 2001-05-30 | — | — | EP | disclosed |
| US-5594024-A | ANTIDEPRESSANTS; TREATMENT OF NARCOLEPSY, SCHIZOPHRENIA, DRUG ABUSE | THE UPJOHN COMPANY (US) | 1997-01-14 | — | — | US | disclosed |
| US-5462947-A | Nervous system disorders | THE UPJOHN COMPANY (US) | 1995-10-31 | — | — | US | disclosed |
| EP-0641320-A1 | NEW CENTRALLY ACTING SUBSTITUTED PHENYLAZACYCLOALKANES | PHARMACIA & UPJOHN COMPANY (US) | 1995-03-08 | — | — | EP | disclosed |
| WO-1992018475-A2 | SUBSTITUTED PHENYLAZACYCLOALKANES AS CNS AGENTS | THE UPJOHN COMPANY (US) | 1992-10-29 | — | — | WO | disclosed |