Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.45 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NAAA | Q02083 | 1/20 | 0.39 |
| ▸ | ACP1 | P24666 | 12/20 | 0.36 |
| ▸ | CPN1 | P15169 | 1/20 | 0.36 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1515268 | 0.88 | SLC6A1 (0.39) | HRH3HRH4 | |
| SCHEMBL9941279 | 0.88 | HRH3 (0.42) | HRH3HRH4KMT2ANAAAACP1 | |
| SCHEMBL7704486 | 0.83 | HRH3 (0.53) | HRH3HRH4KMT2ANAAAACP1 | |
| SCHEMBL11170648 | 0.81 | HRH3 (0.51) | HRH3HRH4KMT2ANAAAACP1 | |
| SCHEMBL22627202 | 0.81 | CYP1A2 (0.48) | — | |
| SCHEMBL1515178 | 0.79 | — | — | |
| SCHEMBL4708069 | 0.79 | HRH3 (0.47) | HRH3HRH4KMT2ANAAACPN1 | |
| SCHEMBL19291884 | 0.78 | HRH3 (0.39) | HRH3HRH4KMT2ACPN1CPB2 | |
| SCHEMBL1515258 | 0.77 | HRH3 (0.41) | HRH3 | |
| SCHEMBL18700760 | 0.77 | HRH3 (0.46) | HRH3HRH4KMT2ANAAACPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0641320-B1 | SUBSTITUTED (S)-3-PHENYLPIPERIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS DOPAMINE AUTORECEPTOR ANTAGONISTS | UPJOHN CO (US) | 2001-05-30 | — | — | EP | disclosed |
| US-5594024-A | ANTIDEPRESSANTS; TREATMENT OF NARCOLEPSY, SCHIZOPHRENIA, DRUG ABUSE | THE UPJOHN COMPANY (US) | 1997-01-14 | — | — | US | disclosed |
| US-5462947-A | Nervous system disorders | THE UPJOHN COMPANY (US) | 1995-10-31 | — | — | US | disclosed |
| EP-0641320-A1 | NEW CENTRALLY ACTING SUBSTITUTED PHENYLAZACYCLOALKANES | PHARMACIA & UPJOHN COMPANY (US) | 1995-03-08 | — | — | EP | disclosed |
| WO-1992018475-A2 | SUBSTITUTED PHENYLAZACYCLOALKANES AS CNS AGENTS | THE UPJOHN COMPANY (US) | 1992-10-29 | — | — | WO | disclosed |