Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 16/20 | 0.62 |
| ▸ | MMP2 | P08253 | 8/20 | 0.62 |
| ▸ | MMP13 | P45452 | 13/20 | 0.53 |
| ▸ | MMP8 | P22894 | 5/20 | 0.53 |
| ▸ | MMP1 | P03956 | 7/20 | 0.50 |
| ▸ | MMP3 | P08254 | 1/20 | 0.50 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.49 |
| ▸ | BMP1 | P13497 | 2/20 | 0.49 |
| ▸ | ADAM17 | P78536 | 5/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7347025 | 1.00 | MMP9 (0.62) | MMP9MMP2MMP13MMP8MMP1 | |
| SCHEMBL609030 | 0.90 | BMP1 (0.50) | MMP9MMP2MMP13MMP8MMP1 | |
| SCHEMBL7355510 | 0.90 | MMP9 (0.54) | MMP9MMP2MMP13MMP8MMP1 | |
| SCHEMBL7353620 | 0.90 | MMP9 (0.54) | MMP9MMP2MMP13MMP8MMP1 | |
| Hydrochloric Acid SCHEMBL7348897 | 0.87 | BMP1 (0.49) | MMP9MMP2MMP13MMP8MMP1 | |
| SCHEMBL7342443 | 0.86 | MMP9 (0.66) | MMP9MMP2MMP13MMP8MMP1 | |
| SCHEMBL7342446 | 0.86 | MMP9 (0.66) | MMP9MMP2MMP13MMP8MMP1 | |
| Hydrochloric Acid SCHEMBL7350105 | 0.86 | MMP9 (0.65) | MMP9MMP2MMP13MMP8MMP1 | |
| Hydrochloric Acid SCHEMBL7350103 | 0.86 | MMP9 (0.65) | MMP9MMP2MMP13MMP8MMP1 | |
| Hydrochloric Acid SCHEMBL7413637 | 0.85 | MMP9 (0.64) | MMP9MMP2MMP13MMP8MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0766672-B1 | ARYLSULFONAMIDO-SUBSTITUTED HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE INHIBITORS | NOVARTIS AG (CH) | 2000-10-04 | — | — | EP | disclosed |
| US-5646167-A | ADMINISTERED AS METALLOPROTEINASE INHIBITOR, ANTITUMOR OR ANTICARCINOGENIC AGENT | CIBA-GEIGY CORPORATION (US) | 1997-07-08 | — | — | US | disclosed |
| EP-0766672-A1 | ARYLSULFONAMIDO-SUBSTITUTED HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE INHIBITORS | Novartis AG (CH) | 1997-04-09 | — | — | EP | disclosed |
| US-5552419-A | METALLOPROTEINASE INHIBITORS | CIBA-GEIGY CORPORATION (US) | 1996-09-03 | — | — | US | disclosed |
| US-5506242-A | METALLOELASTASE INHIBITOR; TREATS EMPHYSEMA | CIBA-GEIGY CORPORATION (US) | 1996-04-09 | — | — | US | disclosed |
| WO-1996000214-A1 | ARYLSULFONAMIDO-SUBSTITUTED HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE INHIBITORS | CIBA-GEIGY AG (CH) | 1996-01-04 | — | — | WO | disclosed |