Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 3/20 | 0.60 |
| ▸ | ADAMTS4 | O75173 | 5/20 | 0.56 |
| ▸ | MMP13 | P45452 | 7/20 | 0.53 |
| ▸ | MMP2 | P08253 | 7/20 | 0.53 |
| ▸ | MMP3 | P08254 | 3/20 | 0.53 |
| ▸ | MMP1 | P03956 | 3/20 | 0.53 |
| ▸ | MMP7 | P09237 | 1/20 | 0.53 |
| ▸ | TARS1 | P26639 | 1/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.47 |
| ▸ | MMP14 | P50281 | 2/20 | 0.45 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.45 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
| ▸ | PGR | P06401 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7355956 | 0.90 | MMP9 (0.48) | MMP9ADAMTS4MMP13MMP2MMP3 | |
| SCHEMBL6271062 | 0.90 | MMP9 (0.57) | MMP9ADAMTS4MMP13MMP2MMP3 | |
| SCHEMBL7347577 | 0.90 | MMP9 (0.54) | MMP9ADAMTS4MMP13MMP2MMP3 | |
| SCHEMBL7417820 | 0.87 | SLC1A3 (0.55) | MMP9ADAMTS4MMP13MMP2MMP3 | |
| SCHEMBL7354064 | 0.87 | MMP9 (0.69) | MMP9ADAMTS4MMP13MMP2MMP3 | |
| SCHEMBL7355442 | 0.85 | MMP9 (0.54) | MMP9ADAMTS4MMP13MMP2MMP3 | |
| SCHEMBL7763089 | 0.84 | MMP9 (0.53) | MMP9ADAMTS4MMP13MMP2MMP3 | |
| SCHEMBL6270601 | 0.81 | MMP9 (0.46) | MMP9ADAMTS4MMP13MMP2MMP3 | |
| SCHEMBL6270025 | 0.79 | MMP9 (0.45) | MMP9ADAMTS4MMP13MMP2MMP3 | |
| SCHEMBL6528257 | 0.79 | ADAM17 (0.67) | MMP9MMP13MMP2MMP1MMP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0973748-A1 | METALLOPROTEINASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR PHARMACEUTICAL USES | AGOURON PHARMACEUTICALS, INC. (US) | 2000-01-26 | — | — | EP | disclosed |
| US-5985900-A | TREATING TUMOR GROWTH, INVASION OR METASTASIS, OSTEOARTHRITIS, RHEUMATOID ARTHRITIS, OSTEOPOROSIS, PERIODONTITIS, GINGIVITIS, CHRONIC DERMAL WOUNDS, CORNEAL ULCERATION, DEGENERATIVE SKIN DISORDERS, MULTIPLE SCLEROSIS, STROKE, ATHEROSCLEROSIS, | AGOURON PHARMACEUTICALS, INC. (US) | 1999-11-16 | — | — | US | disclosed |
| WO-1998043963-A1 | METALLOPROTEINASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR PHARMACEUTICAL USES | AGOURON PHARMACEUTICALS, INC. (US) | 1998-10-08 | — | — | WO | disclosed |