Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 3/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.40 |
| ▸ | CMA1 | P23946 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 4/20 | 0.38 |
| ▸ | PPARG | P37231 | 3/20 | 0.38 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.38 |
| ▸ | CDK1 | P06493 | 2/20 | 0.38 |
| ▸ | CDK4 | P11802 | 2/20 | 0.38 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.38 |
| ▸ | CCND1 | P24385 | 2/20 | 0.38 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.38 |
| ▸ | CETP | P11597 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 2/20 | 0.35 |
| ▸ | AGXT | P21549 | 2/20 | 0.35 |
| ▸ | VNN1 | O95497 | 1/20 | 0.32 |
| ▸ | EPOR | P19235 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 2/20 | 0.32 |
| ▸ | MAOB | P27338 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6201718 | 0.81 | PPARA (0.37) | CHRM2CHRM1CHRM3CMA1PPARA | |
| SCHEMBL7348489 | 0.81 | PPARA (0.38) | CHRM2CHRM1CHRM3CMA1PPARA | |
| SCHEMBL7348493 | 0.81 | PPARA (0.38) | CHRM2CHRM1CHRM3CMA1PPARA | |
| SCHEMBL7296943 | 0.80 | CHRM2 (0.52) | CHRM2CHRM1CHRM3PPARACCNB2 | |
| SCHEMBL9167107 | 0.78 | KMT2A (0.47) | CHRM2CHRM1CHRM3CCNB2CDK1 | |
| SCHEMBL8638304 | 0.78 | ALDH1A1 (0.42) | CHRM2CHRM1CHRM3CMA1PPARA | |
| SCHEMBL8048535 | 0.75 | CHRM2 (0.43) | CHRM2CHRM1CHRM3CMA1PPARA | |
| SCHEMBL1348922 | 0.74 | IDO1 (0.47) | IDO1MAOAMAOBMEN1KMT2A | |
| SCHEMBL30753807 | 0.74 | IDO1 (0.47) | IDO1MAOAMAOBMEN1KMT2A | |
| SCHEMBL9621500 | 0.73 | KDM4E (0.45) | CHRM2CHRM1CHRM3CMA1PPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4514401-A | CARDIOTONICS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1985-04-30 | — | — | US | disclosed |
| US-4487772-A | CARDIOTONIC AGENTS | OTSUKA PHARMACEUTICAL CO. LTD. (JP) | 1984-12-11 | — | — | US | disclosed |
| US-4468402-A | Carbostyril derivatives, process for producing the same and cardiotonic compositions containing the same | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1984-08-28 | — | — | US | disclosed |
| US-4454130-A | CARDIOTONIC, HYPOTENSIVE AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1984-06-12 | — | — | US | disclosed |