Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 12/20 | 0.43 |
| ▸ | ITGA2B | P08514 | 10/20 | 0.43 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.32 |
| ▸ | ITGAV | P06756 | 2/20 | 0.32 |
| ▸ | ITGA5 | P08648 | 2/20 | 0.32 |
| ▸ | MDM4 | O15151 | 1/20 | 0.32 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.32 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.31 |
| ▸ | ITGB6 | P18564 | 1/20 | 0.31 |
| ▸ | ITGB8 | P26012 | 1/20 | 0.31 |
| ▸ | ITGA8 | P53708 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6778246 | 0.83 | FOLH1 (0.32) | — | |
| SCHEMBL6778874 | 0.77 | ITGB3 (0.51) | ITGB3ITGA2BITGB1ITGAVITGA5 | |
| SCHEMBL7348656 | 0.76 | CA1 (0.31) | — | |
| SCHEMBL6773935 | 0.74 | ITGB3 (0.52) | ITGB3ITGA2BITGB1ITGAVITGA5 | |
| SCHEMBL6777472 | 0.74 | ITGB3 (0.52) | ITGB3ITGA2BITGB1ITGAVITGA5 | |
| SCHEMBL6773940 | 0.74 | ITGB3 (0.52) | ITGB3ITGA2BITGB1ITGAVITGA5 | |
| SCHEMBL6783133 | 0.67 | ITGB3 (0.48) | ITGB3ITGA2BITGB1ITGAVITGA5 | |
| SCHEMBL6783814 | 0.67 | ITGB3 (0.42) | ITGB3ITGA2BITGB1ITGAVITGA5 | |
| SCHEMBL6776555 | 0.66 | ITGB3 (0.45) | ITGB3ITGA2BITGB1ITGAVITGA5 | |
| SCHEMBL18553376 | 0.66 | ITGB3 (0.51) | ITGB3ITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0850221-A1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1998-07-01 | — | — | EP | claimed |
| WO-1997008145-A1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1997-03-06 | — | — | WO | claimed |
| EP-0850221-A1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1998-07-01 | — | — | EP | disclosed |
| WO-1997008145-A1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1997-03-06 | — | — | WO | disclosed |