Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE9A | O76083 | 7/20 | 0.39 |
| ▸ | KDM4D | Q6B0I6 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.35 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.34 |
| ▸ | KDM5A | P29375 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7341062 | 0.69 | KDM4E (0.43) | ALDH1A1HPGDPDE4APDE4BPDE4C | |
| SCHEMBL10981876 | 0.67 | ALDH1A1 (0.39) | PDE9AKDM4DALDH1A1HPGDPOLB | |
| SCHEMBL11075425 | 0.66 | PIM1 (0.52) | PDE9AALDH1A1HPGDPOLBHSD11B1 | |
| SCHEMBL11072002 | 0.65 | KDM4D (0.43) | PDE9AKDM4DALDH1A1HPGDHSD11B1 | |
| SCHEMBL10983469 | 0.65 | PDE9A (0.41) | PDE9AALDH1A1HPGDPDE4APDE4B | |
| SCHEMBL10985071 | 0.63 | PDE9A (0.41) | PDE9AKDM4DALDH1A1HPGDPDE4A | |
| SCHEMBL7338198 | 0.63 | KDM5A (0.40) | PDE9AHPGDPDE4APDE4BPDE4C | |
| SCHEMBL11092286 | 0.62 | AURKB (0.38) | PDE4APDE4BPDE4CPDE4DKMT2A | |
| SCHEMBL24063428 | 0.61 | PDE9A (0.76) | PDE9AALDH1A1KCNMA1KDM4EPARP1 | |
| SCHEMBL7336559 | 0.61 | KDM4E (0.46) | ALDH1A1HPGDPDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4511569-A | Tricyclic lactams and derivatives useful in increasing cardiac contractility | SCHERING CORPORATION (US) | 1985-04-16 | — | — | US | disclosed |