Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC1A3 | P43003 | 1/20 | 0.61 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.61 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.61 |
| ▸ | PKLR | P30613 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.49 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.49 |
| ▸ | CASP1 | P29466 | 1/20 | 0.48 |
| ▸ | F2 | P00734 | 4/20 | 0.47 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.47 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.47 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.47 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.46 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.46 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.46 |
| ▸ | MMP1 | P03956 | 1/20 | 0.46 |
| ▸ | MMP2 | P08253 | 1/20 | 0.46 |
| ▸ | MMP9 | P14780 | 1/20 | 0.46 |
| ▸ | MMP8 | P22894 | 1/20 | 0.46 |
| ▸ | ITGAV | P06756 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7348701 | 1.00 | SLC1A3 (0.61) | SLC1A3SLC1A2SLC1A1PKLRTSHR | |
| SCHEMBL5840519 | 0.87 | SLC1A3 (0.64) | SLC1A3SLC1A2SLC1A1TSHRITGB3 | |
| SCHEMBL27575200 | 0.87 | SLC1A3 (0.64) | SLC1A3SLC1A2SLC1A1TSHRITGB3 | |
| SCHEMBL8684370 | 0.87 | SLC1A3 (0.60) | SLC1A3SLC1A2SLC1A1TSHRITGB3 | |
| SCHEMBL27146770 | 0.86 | MMP2 (0.59) | SLC1A3SLC1A2SLC1A1ITGB1ITGA4 | |
| Hydrochloric Acid SCHEMBL6499290 | 0.86 | SLC1A3 (0.62) | SLC1A3SLC1A2SLC1A1TSHRITGB3 | |
| SCHEMBL27146771 | 0.86 | MMP2 (0.59) | SLC1A3SLC1A2SLC1A1ITGB1ITGA4 | |
| SCHEMBL15251811 | 0.85 | SLC1A3 (0.57) | SLC1A3SLC1A2SLC1A1TSHRITGB3 | |
| SCHEMBL7401318 | 0.85 | SLC1A3 (0.57) | SLC1A3SLC1A2SLC1A1PKLRTSHR | |
| SCHEMBL6496422 | 0.85 | SLC1A3 (0.61) | SLC1A3SLC1A2SLC1A1TSHRITGB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5741799-A | ANTICOAGULANTS OF SULFONAMIDO HETEROCYCLIC THROMBIN INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-04-21 | — | — | US | disclosed |
| US-5741792-A | ANTICOAGULANTS OF SULFONAMIDO HETEROCYCLIC THROMBIN INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-04-21 | — | — | US | disclosed |
| US-5583146-A | Heterocyclic thrombin inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-12-10 | — | — | US | disclosed |
| EP-0623595-A1 | Guanidinyl- or amidinyl-substituted heterocyclic thrombin inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 1994-11-09 | — | — | EP | disclosed |