Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 2/20 | 0.51 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.51 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.51 |
| ▸ | LTA4H | P09960 | 1/20 | 0.50 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.49 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.49 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ammonia Solution, Strong SCHEMBL15662547 | 0.98 | PDE3B (0.50) | PDE3BPDE3APDE10ALTA4HCYP11B1 | |
| SCHEMBL28773436 | 0.91 | PDE3B (0.45) | PDE3BPDE3APDE10ALTA4HCYP11B1 | |
| SCHEMBL10621665 | 0.90 | CYP11B1 (0.50) | PDE3BPDE3APDE10ALTA4HCYP11B1 | |
| SCHEMBL5382166 | 0.83 | LTA4H (0.55) | LTA4HCYP11B1CYP11B2CYP19A1CYP2C9 | |
| SCHEMBL23647564 | 0.82 | PDE3B (0.50) | PDE3BPDE3APDE10ALTA4HCYP11B1 | |
| SCHEMBL4279287 | 0.82 | CYP11B1 (0.50) | LTA4HCYP11B1CYP11B2CYP19A1CYP2C9 | |
| SCHEMBL9391619 | 0.82 | NPC1 (0.61) | LTA4HCYP11B1CYP11B2CYP19A1CYP2C9 | |
| SCHEMBL28395651 | 0.82 | RAB9A (0.54) | PDE3BPDE3APDE10ALTA4HRAB9A | |
| Ammonia Solution, Strong SCHEMBL29153964 | 0.80 | PDE3B (0.58) | PDE3BPDE3APDE10ALTA4HRAB9A | |
| SCHEMBL10625865 | 0.78 | CYP11B1 (0.47) | PDE3BPDE3APDE10ALTA4HCYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112292375-B | Substituted alkoxypyridinyl indole sulfonamides | 优时比制药有限公司 | 2023-12-05 | — | — | CN | disclosed |
| CN-110121499-A | (aza) indole-, benzothiophene-and benzofuran-3-sulfonamides | 优时比制药有限公司 | 2019-08-13 | — | — | CN | disclosed |
| CN-109651358-A | 4-aminopyridine derivative, its pharmaceutical composition, preparation method and application | 上海迪诺医药科技有限公司 | 2019-04-19 | — | — | CN | disclosed |
| CN-104755477-B | 2-aminopyridine compounds | 默克专利股份公司 | 2017-09-26 | — | — | CN | disclosed |
| US-4358599-A | Synthesis of 4-amino-1,2-hydrocarbyl pyrazolidines via 4-nitro analogs | A. H. ROBINS COMPANY, INC. (US) | 1982-11-09 | — | — | US | disclosed |
| US-4309552-A | Synthesis of 4-nitro-1,2-hydrocarbyl pyrazolidines and process for preparation thereof | A. H. ROBINS COMPANY, INC. (US) | 1982-01-05 | — | — | US | disclosed |