Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1C | Q13936 | 4/20 | 0.65 |
| ▸ | CACNA1F | O60840 | 3/20 | 0.65 |
| ▸ | CACNA1D | Q01668 | 3/20 | 0.65 |
| ▸ | CACNA1S | Q13698 | 3/20 | 0.65 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.51 |
| ▸ | MAPT | P10636 | 5/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.51 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.51 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.51 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.51 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.51 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.51 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7343709 | 0.86 | CACNA1B (0.52) | CACNA1CCACNA1FCACNA1DCACNA1SADRA1A | |
| SCHEMBL7341777 | 0.86 | CACNA1F (0.63) | CACNA1CCACNA1FCACNA1DCACNA1SADRA1A | |
| SCHEMBL7345495 | 0.86 | POLB (0.58) | CACNA1CCACNA1FCACNA1DCACNA1SADRA1A | |
| SCHEMBL7349297 | 0.86 | CACNA1B (0.57) | CACNA1CCACNA1FCACNA1DCACNA1SADRA1A | |
| SCHEMBL10739603 | 0.86 | ADRA1A (0.69) | CACNA1CCACNA1FCACNA1DCACNA1SADRA1A | |
| SCHEMBL7349495 | 0.84 | CACNA1F (0.65) | CACNA1CCACNA1FCACNA1DCACNA1SADRA1A | |
| SCHEMBL7156469 | 0.84 | CACNA1F (0.76) | CACNA1CCACNA1FCACNA1DCACNA1SMAPT | |
| SCHEMBL7343603 | 0.83 | MAPT (0.70) | CACNA1CADRA1AMAPTCYP1A2CYP3A4 | |
| SCHEMBL7349506 | 0.83 | CACNA1F (0.68) | CACNA1CCACNA1FCACNA1DCACNA1SMAPT | |
| SCHEMBL7156628 | 0.83 | CACNA1F (0.80) | CACNA1CCACNA1FCACNA1DCACNA1SADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4833150-A | HYPOTENSIVES, ANTIARRHYTHMIA AGENTS | NELSON RESEARCH & DEVELOPMENT CO. (US) | 1989-05-23 | — | — | US | disclosed |
| US-4652573-A | HYPOTENSIVE AGENTS | NELSON RESEARCH & DEVELOPMENT CO. (US) | 1987-03-24 | — | — | US | disclosed |
| EP-0194685-A1 | 1,4-Dihydropyridines | Whitby Research Incorporated (US) | 1986-09-17 | — | — | EP | disclosed |