Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 12/20 | 0.63 |
| ▸ | PDE4B | Q07343 | 12/20 | 0.63 |
| ▸ | PDE4C | Q08493 | 12/20 | 0.63 |
| ▸ | PDE4D | Q08499 | 12/20 | 0.63 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7338886 | 0.78 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| Hydrochloric Acid SCHEMBL7341944 | 0.77 | PDE4A (0.97) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL7340789 | 0.75 | PDE4A (0.69) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL11802077 | 0.74 | CYP19A1 (0.56) | IDO1CYP3A4CYP1A2CYP2C9PMP22 | |
| SCHEMBL1132341 | 0.74 | IDO1 (0.57) | IDO1CYP3A4CYP1A2CYP2C9PMP22 | |
| SCHEMBL5194347 | 0.73 | IDO1 (0.47) | PDE4APDE4BPDE4CPDE4DIDO1 | |
| SCHEMBL726313 | 0.72 | IDO1 (0.59) | IDO1CYP3A4CYP1A2CYP2C9PMP22 | |
| SCHEMBL11775831 | 0.72 | IDO1 (0.51) | IDO1CYP3A4CYP1A2CYP2C9PMP22 | |
| SCHEMBL6601781 | 0.71 | IDO1 (0.57) | IDO1CYP3A4CYP1A2CYP2C9PMP22 | |
| SCHEMBL7364258 | 0.71 | IDO1 (0.57) | IDO1CYP3A4CYP1A2CYP2C9PMP22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0169164-B1 | IMIDAZOLONECARBONYLARYLIMIDAZOLES; METHOD OF MANUFACTURE, METHOD OF USE AND COMPOSITIONS USEFUL THEREOF | SCHERING AKTIENGESELLSCHAFT (DE) | 1990-01-31 | — | — | EP | disclosed |
| US-4709043-A | Process for the preparation of imidazolonecarbonylarylimidazoles | SCHERING A.G. (DE) | 1987-11-24 | — | — | US | disclosed |
| EP-0169164-A1 | Imidazolonecarbonylarylimidazoles; method of manufacture, method of use and compositions useful thereof | SCHERING AKTIENGESELLSCHAFT (DE) | 1986-01-22 | — | — | EP | disclosed |
| US-4556665-A | Cardiotonic 1,3-dihydro-4-[[(imidazol-1-yl)aryl]carbonyl]imidazol-2-ones | SCHERING A.G. (DE) | 1985-12-03 | — | — | US | disclosed |