SCHEMBL7350221

SCHEMBL7350221

C=CCN(C)C1CCCN(C(=O)c2ccc(NC(=O)c3ccccc3Cl)c(OC)c2)c2ccc(Cl)cc21

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SPTLC2 O15270 3/20 0.51
AVPR1A P37288 6/20 0.51
AVPR2 P30518 5/20 0.51
AVPR1B P47901 2/20 0.51
ALDH1A1 P00352 1/20 0.43
LMNA P02545 1/20 0.43
ABCB11 O95342 1/20 0.43
ADRB2 P07550 1/20 0.43
HTR1A P08908 1/20 0.43
ADORA3 P0DMS8 1/20 0.43
CHRM1 P11229 1/20 0.43
TBXA2R P21731 1/20 0.43
HTR2C P28335 1/20 0.43
HRH1 P35367 1/20 0.43
OPRM1 P35372 1/20 0.43
GLP1R P43220 1/20 0.43
TMEM97 Q5BJF2 1/20 0.43
FFAR4 Q5NUL3 1/20 0.43
GPR119 Q8TDV5 1/20 0.43
GRM4 Q14833 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7354620 0.85 AVPR2 (0.53) AVPR1AAVPR2AVPR1BABCB11ADRB2
SCHEMBL7355275 0.83 AVPR1A (0.61) AVPR1AAVPR2AVPR1BALDH1A1ABCB11
SCHEMBL7353539 0.83 SPTLC2 (0.59) SPTLC2AVPR1AAVPR2AVPR1BALDH1A1
SCHEMBL7350492 0.83 SPTLC2 (0.52) SPTLC2AVPR1AAVPR2AVPR1BALDH1A1
SCHEMBL7344136 0.83 AVPR1A (0.61) SPTLC2AVPR1AAVPR2AVPR1BALDH1A1
SCHEMBL7353531 0.82 AVPR1A (0.64) AVPR1AAVPR2AVPR1BABCB11ADRB2
SCHEMBL7353259 0.82 SPTLC2 (0.57) SPTLC2AVPR1AAVPR2AVPR1BALDH1A1
SCHEMBL7353530 0.81 SPTLC2 (0.51) SPTLC2AVPR1AAVPR2AVPR1BALDH1A1
SCHEMBL7344114 0.81 AVPR1A (0.58) SPTLC2AVPR1AAVPR2AVPR1BABCB11
Hydrochloric Acid SCHEMBL7355159 0.81 SPTLC2 (0.52) SPTLC2AVPR1AAVPR2AVPR1BALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1994001113-A1 OXYTOCIN ANTAGONIST OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) 1994-01-20 WO disclosed