Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPTLC2 | O15270 | 3/20 | 0.57 |
| ▸ | AVPR2 | P30518 | 8/20 | 0.50 |
| ▸ | AVPR1A | P37288 | 5/20 | 0.50 |
| ▸ | AVPR1B | P47901 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.47 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.46 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | HRH1 | P35367 | 1/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.46 |
| ▸ | GLP1R | P43220 | 1/20 | 0.46 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.46 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.46 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7356074 | 0.93 | AVPR2 (0.55) | SPTLC2AVPR2AVPR1AALDH1A1ABCB11 | |
| SCHEMBL7353539 | 0.92 | SPTLC2 (0.59) | SPTLC2AVPR2AVPR1AAVPR1BALDH1A1 | |
| SCHEMBL7352545 | 0.86 | AVPR1A (0.55) | AVPR2AVPR1AAVPR1BABCB11ADRB2 | |
| SCHEMBL7351581 | 0.85 | AVPR2 (0.57) | SPTLC2AVPR2AVPR1AALDH1A1ABCB11 | |
| Hydrochloric Acid SCHEMBL7355159 | 0.83 | SPTLC2 (0.52) | SPTLC2AVPR2AVPR1AAVPR1BALDH1A1 | |
| SCHEMBL7350492 | 0.83 | SPTLC2 (0.52) | SPTLC2AVPR2AVPR1AAVPR1BALDH1A1 | |
| SCHEMBL7353530 | 0.82 | SPTLC2 (0.51) | SPTLC2AVPR2AVPR1AAVPR1BALDH1A1 | |
| SCHEMBL7349412 | 0.82 | SPTLC2 (0.51) | SPTLC2AVPR2AVPR1AAVPR1BALDH1A1 | |
| SCHEMBL7350221 | 0.82 | SPTLC2 (0.51) | SPTLC2AVPR2AVPR1AAVPR1BALDH1A1 | |
| Hydrochloric Acid SCHEMBL4686990 | 0.81 | SPTLC2 (0.50) | SPTLC2AVPR2AVPR1AAVPR1BALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5985869-A | USEFUL AS VASODILATORS, HYPOTENSIVE AGENTS, WATER DIURETICS, PLATELET AGGLUTINATION INHIBITORS | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1999-11-16 | — | — | US | disclosed |
| US-5753677-A | Benzoheterocyclic compounds | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1998-05-19 | — | — | US | disclosed |
| US-5559230-A | VASOPRESSIN ANTAGONISTS, QUINOLINES, BENZAZEPINES, VASODILATION, HYPOTENSIVE AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1996-09-24 | — | — | US | disclosed |