Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.71 |
| ▸ | AVPR1A | P37288 | 2/20 | 0.68 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.67 |
| ▸ | OXTR | P30559 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7353560 | 0.92 | TSHR (0.72) | TSHRAVPR1AAVPR2OXTRALDH1A1 | |
| SCHEMBL7348562 | 0.91 | TSHR (0.70) | TSHRAVPR1AAVPR2OXTRALDH1A1 | |
| SCHEMBL7350530 | 0.89 | TSHR (0.77) | TSHRALDH1A1 | |
| SCHEMBL7354099 | 0.89 | ALDH1A1 (0.80) | TSHRALDH1A1 | |
| SCHEMBL7348778 | 0.85 | AVPR1A (0.76) | AVPR1AAVPR2OXTR | |
| SCHEMBL7352530 | 0.84 | AVPR1A (0.69) | AVPR1AAVPR2OXTR | |
| SCHEMBL7355637 | 0.84 | AVPR1A (0.77) | AVPR1AAVPR2OXTR | |
| SCHEMBL7349166 | 0.84 | AVPR1A (0.74) | AVPR1AAVPR2OXTR | |
| SCHEMBL7349028 | 0.84 | AVPR1A (0.76) | AVPR1AAVPR2OXTR | |
| SCHEMBL7347903 | 0.84 | ALDH1A1 (0.75) | TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5985869-A | USEFUL AS VASODILATORS, HYPOTENSIVE AGENTS, WATER DIURETICS, PLATELET AGGLUTINATION INHIBITORS | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1999-11-16 | — | — | US | disclosed |
| US-5753677-A | Benzoheterocyclic compounds | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1998-05-19 | — | — | US | disclosed |
| US-5559230-A | VASOPRESSIN ANTAGONISTS, QUINOLINES, BENZAZEPINES, VASODILATION, HYPOTENSIVE AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1996-09-24 | — | — | US | disclosed |
| EP-0450097-B1 | BENZOHETEROCYCLIC COMPOUNDS | OTSUKA PHARMA CO LTD (JP) | 1996-04-24 | — | — | EP | disclosed |
| WO-1991005549-A1 | BENZOHETEROCYCLIC COMPOUNDS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1991-05-02 | — | — | WO | disclosed |