Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 8/20 | 0.50 |
| ▸ | MMP9 | P14780 | 8/20 | 0.50 |
| ▸ | MMP1 | P03956 | 4/20 | 0.50 |
| ▸ | ADAM17 | P78536 | 7/20 | 0.48 |
| ▸ | MMP3 | P08254 | 1/20 | 0.43 |
| ▸ | MMP7 | P09237 | 1/20 | 0.43 |
| ▸ | MMP8 | P22894 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.43 |
| ▸ | MMP14 | P50281 | 1/20 | 0.43 |
| ▸ | MMP15 | P51511 | 1/20 | 0.43 |
| ▸ | MMP16 | P51512 | 1/20 | 0.43 |
| ▸ | ADAM33 | Q9BZ11 | 1/20 | 0.43 |
| ▸ | TACR2 | P21452 | 5/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6630275 | 0.84 | MMP2 (0.52) | MMP2MMP9MMP1ADAM17MMP3 | |
| SCHEMBL7472135 | 0.83 | ADAM17 (0.58) | MMP2MMP9MMP1ADAM17MMP3 | |
| SCHEMBL7354732 | 0.83 | ADAM17 (0.60) | MMP2MMP9MMP1ADAM17MMP3 | |
| SCHEMBL6628825 | 0.82 | MMP2 (0.57) | MMP2MMP9MMP1ADAM17MMP3 | |
| SCHEMBL7362674 | 0.81 | MMP2 (0.53) | MMP2MMP9MMP1ADAM17MMP3 | |
| SCHEMBL7421348 | 0.80 | ADAM17 (0.61) | MMP2MMP9MMP1ADAM17MMP3 | |
| SCHEMBL7469593 | 0.80 | ADAM17 (0.51) | MMP2MMP9MMP1ADAM17MMP3 | |
| SCHEMBL7361032 | 0.80 | MMP2 (0.54) | MMP2MMP9MMP1ADAM17MMP3 | |
| SCHEMBL6628534 | 0.79 | MMP2 (0.55) | MMP2MMP9MMP1ADAM17MMP3 | |
| Trifluoroacetic Acid SCHEMBL6626493 | 0.78 | ADAM17 (0.54) | MMP2MMP9MMP1ADAM17MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1027332-A1 | NOVEL LACTAM METALLOPROTEASE INHIBITORS | Du Pont Pharmaceuticals Company (US) | 2000-08-16 | — | — | EP | disclosed |
| WO-1999018074-A1 | NOVEL LACTAM METALLOPROTEASE INHIBITORS | Britol-Myers Squibb Pharma Company (US) | 1999-04-15 | — | — | WO | disclosed |