SCHEMBL7350556

SCHEMBL7350556

CCCNc1c(Nc2cccnc2)c(=O)c1=O

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPKAPK2 P49137 1/20 0.43
RAD52 P43351 2/20 0.43
KMT2A Q03164 2/20 0.43
TDP2 O95551 1/20 0.43
NSD2 O96028 1/20 0.43
CHEK2 O96017 3/20 0.42
PRKACA P17612 3/20 0.42
RPS6KB1 P23443 3/20 0.42
GSK3A P49840 3/20 0.42
GSK3B P49841 3/20 0.42
RPS6KA3 P51812 3/20 0.42
ROCK1 Q13464 3/20 0.42
PRKG1 Q13976 3/20 0.42
PKN2 Q16513 3/20 0.42
CDC42BPA Q5VT25 3/20 0.42
HIPK4 Q8NE63 3/20 0.42
AURKB Q96GD4 3/20 0.42
CSNK1G3 Q9Y6M4 3/20 0.42
CHEK1 O14757 2/20 0.42
PRKCD Q05655 2/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19956891 0.80 KMT2A (0.49) MAPKAPK2RAD52KMT2ATDP2NSD2
SCHEMBL3643530 0.79 RAB9A (0.54) RAD52KMT2ALMNAPOLBFLT4
SCHEMBL4024804 0.78 FLT4 (0.47) MAPKAPK2KMT2ACHEK2PRKACARPS6KB1
SCHEMBL4028515 0.76 HDAC1 (0.47) CHEK2PRKACARPS6KB1GSK3AGSK3B
SCHEMBL4026908 0.76 HDAC1 (0.48) MAPKAPK2RAD52KMT2AFLT4FES
SCHEMBL7349452 0.76 PLK1 (0.55) MAPKAPK2RAD52KMT2ATDP2NSD2
SCHEMBL4023982 0.75 POLB (0.55) RAD52KMT2ALMNAPOLBRAB9A
SCHEMBL4027877 0.75 FES (0.77) MAPKAPK2RAD52KMT2ALMNAPOLB
SCHEMBL8667012 0.74 RAD52 (0.41) RAD52KMT2ATDP2NSD2LMNA
SCHEMBL4024922 0.74 MAPKAPK2 (0.61) MAPKAPK2RAD52KMT2ACHEK2PRKACA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0729457-B1 DIAMINOCYCLOBUTENE-3,4-DIONES AS SMOOTH MUSCLE RELAXANTS AMERICAN HOME PROD (US) 1998-12-23 EP claimed
EP-0729457-A1 DIAMINOCYCLOBUTENE-3,4-DIONES AS SMOOTH MUSCLE RELAXANTS AMERICAN HOME PRODUCTS CORPORATION (US) 1996-09-04 EP claimed
WO-1995014005-A1 DIAMINOCYCLOBUTENE-3,4-DIONES AS SMOOTH MUSCLE RELAXANTS AMERICAN HOME PRODUCTS CORPORATION (US) 1995-05-26 WO claimed
US-5354763-A Smooth muscle relaxants AMERICAN HOME PRODUCTS CORPORATION (US) 1994-10-11 US claimed
EP-0729457-B1 DIAMINOCYCLOBUTENE-3,4-DIONES AS SMOOTH MUSCLE RELAXANTS AMERICAN HOME PROD (US) 1998-12-23 EP disclosed
US-5506252-A MUSCLE RELAXANTS AMERICAN HOME PRODUCTS CORPORATION (US) 1996-04-09 US disclosed
US-5403853-A Smooth muscle relaxants AMERICAN HOME PRODUCTS CORPORATION (US) 1995-04-04 US disclosed
US-5401753-A Smooth muscle relaxants for urogenital disorders AMERICAN HOME PRODUCTS CORPORATION (US) 1995-03-28 US disclosed
US-5397790-A Smooth muscle relaxants AMERICAN HOME PRODUCTS CORPORATION (US) 1995-03-14 US disclosed