Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 7/20 | 0.52 |
| ▸ | NPC1 | O15118 | 4/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | GPR17 | Q13304 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6777924 | 0.83 | ALDH1A1 (0.62) | ALDH1A1SMN1; SMN2TP53RAB9ANPC1 | |
| SCHEMBL23455503 | 0.83 | ALDH1A1 (0.62) | ALDH1A1SMN1; SMN2TP53RAB9ANPC1 | |
| SCHEMBL6777923 | 0.83 | ALDH1A1 (0.62) | ALDH1A1SMN1; SMN2TP53RAB9ANPC1 | |
| SCHEMBL6772413 | 0.80 | RAB9A (0.59) | ALDH1A1SMN1; SMN2TP53RAB9ANPC1 | |
| SCHEMBL6772415 | 0.80 | RAB9A (0.59) | ALDH1A1SMN1; SMN2TP53RAB9ANPC1 | |
| SCHEMBL6772589 | 0.79 | RAB9A (0.51) | ALDH1A1SMN1; SMN2TP53RAB9ANPC1 | |
| SCHEMBL6772591 | 0.79 | RAB9A (0.51) | ALDH1A1SMN1; SMN2TP53RAB9ANPC1 | |
| SCHEMBL6779219 | 0.79 | RAB9A (0.53) | ALDH1A1SMN1; SMN2TP53RAB9ANPC1 | |
| SCHEMBL6779224 | 0.79 | RAB9A (0.53) | ALDH1A1SMN1; SMN2TP53RAB9ANPC1 | |
| SCHEMBL7467415 | 0.78 | ALDH1A1 (0.66) | ALDH1A1SMN1; SMN2TP53RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0889875-A1 | CYCLOPROPYL ALKANOIC ACID DERIVATIVES | G.D. SEARLE & CO. (US) | 1999-01-13 | — | — | EP | disclosed |
| WO-1997036858-A1 | CYCLOPROPYL ALKANOIC ACID DERIVATIVES | G.D. SEARLE & CO. (US) | 1997-10-09 | — | — | WO | disclosed |